Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain

Abstract Use of maternal oxygen for intrauterine resuscitation is contentious because of the lack of evidence for its efficacy and the possibility of fetal harm through oxidative stress. Because the developing brain is rich in lipids and low in antioxidants, it remains vulnerable to oxidative stress...

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Autores principales:	Jia Jiang, Tusar Giri, Nandini Raghuraman, Alison G. Cahill, Arvind Palanisamy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22b0e45b5ac94c2699aa2baff9cc9913
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spelling	oai:doaj.org-article:22b0e45b5ac94c2699aa2baff9cc99132021-12-02T14:29:04ZImpact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain10.1038/s41598-021-89299-w2045-2322https://doaj.org/article/22b0e45b5ac94c2699aa2baff9cc99132021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89299-whttps://doaj.org/toc/2045-2322Abstract Use of maternal oxygen for intrauterine resuscitation is contentious because of the lack of evidence for its efficacy and the possibility of fetal harm through oxidative stress. Because the developing brain is rich in lipids and low in antioxidants, it remains vulnerable to oxidative stress. Here, we tested this hypothesis in a term pregnant rat model with oxytocin-induced fetal distress followed by treatment with either room air or 100% oxygen for 6 h. Fetal brains from both sexes were subjected to assays for biomarkers of oxidative stress (4-hydroxynonenal, protein carbonyl, or 8-hydroxy-2ʹ-deoxyguanosine), expression of genes mediating oxidative stress, and mitochondrial oxidative phosphorylation. Contrary to our hypothesis, maternal hyperoxia was not associated with increased biomarkers of oxidative stress in the fetal brain. However, there was significant upregulation of the expression of select genes mediating oxidative stress, of which some were male-specific. These observations, however, were not accompanied by changes in the expression of proteins from the mitochondrial electron transport chain. In summary, maternal hyperoxia in the setting of acute uteroplacental ischemia-hypoxia does not appear to cause oxidative damage to the developing brain.Jia JiangTusar GiriNandini RaghuramanAlison G. CahillArvind PalanisamyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jia Jiang Tusar Giri Nandini Raghuraman Alison G. Cahill Arvind Palanisamy Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain
description	Abstract Use of maternal oxygen for intrauterine resuscitation is contentious because of the lack of evidence for its efficacy and the possibility of fetal harm through oxidative stress. Because the developing brain is rich in lipids and low in antioxidants, it remains vulnerable to oxidative stress. Here, we tested this hypothesis in a term pregnant rat model with oxytocin-induced fetal distress followed by treatment with either room air or 100% oxygen for 6 h. Fetal brains from both sexes were subjected to assays for biomarkers of oxidative stress (4-hydroxynonenal, protein carbonyl, or 8-hydroxy-2ʹ-deoxyguanosine), expression of genes mediating oxidative stress, and mitochondrial oxidative phosphorylation. Contrary to our hypothesis, maternal hyperoxia was not associated with increased biomarkers of oxidative stress in the fetal brain. However, there was significant upregulation of the expression of select genes mediating oxidative stress, of which some were male-specific. These observations, however, were not accompanied by changes in the expression of proteins from the mitochondrial electron transport chain. In summary, maternal hyperoxia in the setting of acute uteroplacental ischemia-hypoxia does not appear to cause oxidative damage to the developing brain.
format	article
author	Jia Jiang Tusar Giri Nandini Raghuraman Alison G. Cahill Arvind Palanisamy
author_facet	Jia Jiang Tusar Giri Nandini Raghuraman Alison G. Cahill Arvind Palanisamy
author_sort	Jia Jiang
title	Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain
title_short	Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain
title_full	Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain
title_fullStr	Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain
title_full_unstemmed	Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain
title_sort	impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/22b0e45b5ac94c2699aa2baff9cc9913
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Impact of intrauterine fetal resuscitation with oxygen on oxidative stress in the developing rat brain

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