Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange

Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange

Thiol-disulfide exchange is an extensively used reversible reaction in dynamic combinatorial chemistry, but usually requires long time to reach equilibrium. Here, the authors employ selenocystine as a catalyst of thiol-disulfide exchange at low temperatures and basic pH, and show that it can promote...

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Autores principales: Andrea Canal-Martín, Ruth Pérez-Fernández
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/22b1d46511d6430886e277acb51671e4
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spelling oai:doaj.org-article:22b1d46511d6430886e277acb51671e42021-12-02T15:16:22ZBiomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange10.1038/s41467-020-20415-62041-1723https://doaj.org/article/22b1d46511d6430886e277acb51671e42021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20415-6https://doaj.org/toc/2041-1723Thiol-disulfide exchange is an extensively used reversible reaction in dynamic combinatorial chemistry, but usually requires long time to reach equilibrium. Here, the authors employ selenocystine as a catalyst of thiol-disulfide exchange at low temperatures and basic pH, and show that it can promote disulfide bond formation during folding of a scrambled RNase A.Andrea Canal-MartínRuth Pérez-FernándezNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Andrea Canal-Martín
Ruth Pérez-Fernández
Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange
description Thiol-disulfide exchange is an extensively used reversible reaction in dynamic combinatorial chemistry, but usually requires long time to reach equilibrium. Here, the authors employ selenocystine as a catalyst of thiol-disulfide exchange at low temperatures and basic pH, and show that it can promote disulfide bond formation during folding of a scrambled RNase A.
format article
author Andrea Canal-Martín
Ruth Pérez-Fernández
author_facet Andrea Canal-Martín
Ruth Pérez-Fernández
author_sort Andrea Canal-Martín
title Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange
title_short Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange
title_full Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange
title_fullStr Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange
title_full_unstemmed Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange
title_sort biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/22b1d46511d6430886e277acb51671e4
work_keys_str_mv AT andreacanalmartin biomimeticselenocystinebaseddynamiccombinatorialchemistryforthioldisulfideexchange
AT ruthperezfernandez biomimeticselenocystinebaseddynamiccombinatorialchemistryforthioldisulfideexchange
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