Molecular architecture and regulation of BCL10-MALT1 filaments

The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies.

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Autores principales:	Florian Schlauderer, Thomas Seeholzer, Ambroise Desfosses, Torben Gehring, Mike Strauss, Karl-Peter Hopfner, Irina Gutsche, Daniel Krappmann, Katja Lammens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22b52c92e3104c5888ae0b4dd5745f98
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spelling	oai:doaj.org-article:22b52c92e3104c5888ae0b4dd5745f982021-12-02T15:34:50ZMolecular architecture and regulation of BCL10-MALT1 filaments10.1038/s41467-018-06573-82041-1723https://doaj.org/article/22b52c92e3104c5888ae0b4dd5745f982018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06573-8https://doaj.org/toc/2041-1723The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies.Florian SchlaudererThomas SeeholzerAmbroise DesfossesTorben GehringMike StraussKarl-Peter HopfnerIrina GutscheDaniel KrappmannKatja LammensNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florian Schlauderer Thomas Seeholzer Ambroise Desfosses Torben Gehring Mike Strauss Karl-Peter Hopfner Irina Gutsche Daniel Krappmann Katja Lammens Molecular architecture and regulation of BCL10-MALT1 filaments
description	The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies.
format	article
author	Florian Schlauderer Thomas Seeholzer Ambroise Desfosses Torben Gehring Mike Strauss Karl-Peter Hopfner Irina Gutsche Daniel Krappmann Katja Lammens
author_facet	Florian Schlauderer Thomas Seeholzer Ambroise Desfosses Torben Gehring Mike Strauss Karl-Peter Hopfner Irina Gutsche Daniel Krappmann Katja Lammens
author_sort	Florian Schlauderer
title	Molecular architecture and regulation of BCL10-MALT1 filaments
title_short	Molecular architecture and regulation of BCL10-MALT1 filaments
title_full	Molecular architecture and regulation of BCL10-MALT1 filaments
title_fullStr	Molecular architecture and regulation of BCL10-MALT1 filaments
title_full_unstemmed	Molecular architecture and regulation of BCL10-MALT1 filaments
title_sort	molecular architecture and regulation of bcl10-malt1 filaments
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/22b52c92e3104c5888ae0b4dd5745f98
work_keys_str_mv	AT florianschlauderer moleculararchitectureandregulationofbcl10malt1filaments AT thomasseeholzer moleculararchitectureandregulationofbcl10malt1filaments AT ambroisedesfosses moleculararchitectureandregulationofbcl10malt1filaments AT torbengehring moleculararchitectureandregulationofbcl10malt1filaments AT mikestrauss moleculararchitectureandregulationofbcl10malt1filaments AT karlpeterhopfner moleculararchitectureandregulationofbcl10malt1filaments AT irinagutsche moleculararchitectureandregulationofbcl10malt1filaments AT danielkrappmann moleculararchitectureandregulationofbcl10malt1filaments AT katjalammens moleculararchitectureandregulationofbcl10malt1filaments
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Molecular architecture and regulation of BCL10-MALT1 filaments

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