An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
Mutations in proteins that localize to primary cilia cause devastating diseases, yet the primary cilium is a poorly understood organelle. Here the authors use interaction proteomics to identify a network of human ciliary proteins that provides new insights into several biological processes and disea...
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Nature Portfolio
2016
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oai:doaj.org-article:22bd7d5adfdc431187d2dc80408e8af02021-12-02T14:39:31ZAn organelle-specific protein landscape identifies novel diseases and molecular mechanisms10.1038/ncomms114912041-1723https://doaj.org/article/22bd7d5adfdc431187d2dc80408e8af02016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11491https://doaj.org/toc/2041-1723Mutations in proteins that localize to primary cilia cause devastating diseases, yet the primary cilium is a poorly understood organelle. Here the authors use interaction proteomics to identify a network of human ciliary proteins that provides new insights into several biological processes and diseases.Karsten BoldtJeroen van ReeuwijkQianhao LuKonstantinos KoutroumpasThanh-Minh T. NguyenYves TexierSylvia E. C. van BeersumNicola HornJason R. WillerDorus A. MansGerard DoughertyIdeke J. C. LamersKarlien L. M. CoeneHeleen H. ArtsMatthew J. BettsTina BeyerEmine BolatChristian Johannes GloecknerKhatera HaidariLisette HetterschijtDaniela IaconisDagan JenkinsFranziska KloseBarbara KnappBrooke LatourStef J. F. LetteboerCarlo L. MarcelisDragana MiticManuela MorleoMachteld M. OudMoniek RiemersmaSusan RixPaulien A. TerhalGrischa ToedtTeunis J. P. van DamErik de VriezeYasmin WissingerKa Man WuGordana ApicPhilip L. BealesOliver E. BlacqueToby J. GibsonMartijn A. HuynenNicholas KatsanisHannie KremerHeymut OmranErwin van WijkUwe WolfrumFrançois KepesErica E. DavisBrunella FrancoRachel H. GilesMarius UeffingRobert B. RussellRonald RoepmanUK10K Rare Diseases GroupNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
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DOAJ |
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EN |
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Science Q |
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Science Q Karsten Boldt Jeroen van Reeuwijk Qianhao Lu Konstantinos Koutroumpas Thanh-Minh T. Nguyen Yves Texier Sylvia E. C. van Beersum Nicola Horn Jason R. Willer Dorus A. Mans Gerard Dougherty Ideke J. C. Lamers Karlien L. M. Coene Heleen H. Arts Matthew J. Betts Tina Beyer Emine Bolat Christian Johannes Gloeckner Khatera Haidari Lisette Hetterschijt Daniela Iaconis Dagan Jenkins Franziska Klose Barbara Knapp Brooke Latour Stef J. F. Letteboer Carlo L. Marcelis Dragana Mitic Manuela Morleo Machteld M. Oud Moniek Riemersma Susan Rix Paulien A. Terhal Grischa Toedt Teunis J. P. van Dam Erik de Vrieze Yasmin Wissinger Ka Man Wu Gordana Apic Philip L. Beales Oliver E. Blacque Toby J. Gibson Martijn A. Huynen Nicholas Katsanis Hannie Kremer Heymut Omran Erwin van Wijk Uwe Wolfrum François Kepes Erica E. Davis Brunella Franco Rachel H. Giles Marius Ueffing Robert B. Russell Ronald Roepman UK10K Rare Diseases Group An organelle-specific protein landscape identifies novel diseases and molecular mechanisms |
| description |
Mutations in proteins that localize to primary cilia cause devastating diseases, yet the primary cilium is a poorly understood organelle. Here the authors use interaction proteomics to identify a network of human ciliary proteins that provides new insights into several biological processes and diseases. |
| format |
article |
| author |
Karsten Boldt Jeroen van Reeuwijk Qianhao Lu Konstantinos Koutroumpas Thanh-Minh T. Nguyen Yves Texier Sylvia E. C. van Beersum Nicola Horn Jason R. Willer Dorus A. Mans Gerard Dougherty Ideke J. C. Lamers Karlien L. M. Coene Heleen H. Arts Matthew J. Betts Tina Beyer Emine Bolat Christian Johannes Gloeckner Khatera Haidari Lisette Hetterschijt Daniela Iaconis Dagan Jenkins Franziska Klose Barbara Knapp Brooke Latour Stef J. F. Letteboer Carlo L. Marcelis Dragana Mitic Manuela Morleo Machteld M. Oud Moniek Riemersma Susan Rix Paulien A. Terhal Grischa Toedt Teunis J. P. van Dam Erik de Vrieze Yasmin Wissinger Ka Man Wu Gordana Apic Philip L. Beales Oliver E. Blacque Toby J. Gibson Martijn A. Huynen Nicholas Katsanis Hannie Kremer Heymut Omran Erwin van Wijk Uwe Wolfrum François Kepes Erica E. Davis Brunella Franco Rachel H. Giles Marius Ueffing Robert B. Russell Ronald Roepman UK10K Rare Diseases Group |
| author_facet |
Karsten Boldt Jeroen van Reeuwijk Qianhao Lu Konstantinos Koutroumpas Thanh-Minh T. Nguyen Yves Texier Sylvia E. C. van Beersum Nicola Horn Jason R. Willer Dorus A. Mans Gerard Dougherty Ideke J. C. Lamers Karlien L. M. Coene Heleen H. Arts Matthew J. Betts Tina Beyer Emine Bolat Christian Johannes Gloeckner Khatera Haidari Lisette Hetterschijt Daniela Iaconis Dagan Jenkins Franziska Klose Barbara Knapp Brooke Latour Stef J. F. Letteboer Carlo L. Marcelis Dragana Mitic Manuela Morleo Machteld M. Oud Moniek Riemersma Susan Rix Paulien A. Terhal Grischa Toedt Teunis J. P. van Dam Erik de Vrieze Yasmin Wissinger Ka Man Wu Gordana Apic Philip L. Beales Oliver E. Blacque Toby J. Gibson Martijn A. Huynen Nicholas Katsanis Hannie Kremer Heymut Omran Erwin van Wijk Uwe Wolfrum François Kepes Erica E. Davis Brunella Franco Rachel H. Giles Marius Ueffing Robert B. Russell Ronald Roepman UK10K Rare Diseases Group |
| author_sort |
Karsten Boldt |
| title |
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms |
| title_short |
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms |
| title_full |
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms |
| title_fullStr |
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms |
| title_full_unstemmed |
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms |
| title_sort |
organelle-specific protein landscape identifies novel diseases and molecular mechanisms |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/22bd7d5adfdc431187d2dc80408e8af0 |
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