Impaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice

Background: Gamma-aminobutyric acid (GABA) type A receptors are positively allosterically modulated by benzodiazepine binding, leading to a potentiated response to GABA. Diazepam (DZP, a benzodiazepine) is widely prescribed for anxiety, epileptic discharge, and insomnia, and is also used as a muscle...

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Main Authors: Tomonori Furukawa, Yoshikazu Nikaido, Shuji Shimoyama, Nozomu Masuyama, Ayaka Notoya, Shinya Ueno
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
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Online Access:https://doaj.org/article/22c0615e4b604b4b81e1443b6dbc2ae5
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