Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults
Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/ri...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/22c1c90570df4dbf91dba7f67b782e71 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:22c1c90570df4dbf91dba7f67b782e71 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:22c1c90570df4dbf91dba7f67b782e712021-11-17T05:09:21ZAssociations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults2297-055X10.3389/fcvm.2021.710023https://doaj.org/article/22c1c90570df4dbf91dba7f67b782e712021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.710023/fullhttps://doaj.org/toc/2297-055XBackground: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk.Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension.Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 ± 1.1 vs. 34.7 ± 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972–0.984)] in Hanzhong Adolescent Hypertension Study cohort.Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension.Yang WangYang WangMing-Fei DuShi YaoTing ZouXiao-Yu ZhangGui-Lin HuChao ChuChao ChuYue-Yuan LiaoYue-Yuan LiaoChen ChenDan WangDan WangQiong MaQiong MaKe-Ke WangKe-Ke WangYue SunYue SunZe-Jiaxin NiuZe-Jiaxin NiuRui-Chen YanRui-Chen YanYu YanYu YanHao-Wei ZhouHao JiaWei-Hua GaoHao LiChun-Hua LiFang-Yao ChenKe GaoJie ZhangRobert SafirsteinFeng WangTie-Lin YangJian-Jun MuJian-Jun MuFrontiers Media S.A.articlegene polymorphismhypertensionuromodulin (UMOD)longitudinal changeblood pressureDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
gene polymorphism hypertension uromodulin (UMOD) longitudinal change blood pressure Diseases of the circulatory (Cardiovascular) system RC666-701 |
| spellingShingle |
gene polymorphism hypertension uromodulin (UMOD) longitudinal change blood pressure Diseases of the circulatory (Cardiovascular) system RC666-701 Yang Wang Yang Wang Ming-Fei Du Shi Yao Ting Zou Xiao-Yu Zhang Gui-Lin Hu Chao Chu Chao Chu Yue-Yuan Liao Yue-Yuan Liao Chen Chen Dan Wang Dan Wang Qiong Ma Qiong Ma Ke-Ke Wang Ke-Ke Wang Yue Sun Yue Sun Ze-Jiaxin Niu Ze-Jiaxin Niu Rui-Chen Yan Rui-Chen Yan Yu Yan Yu Yan Hao-Wei Zhou Hao Jia Wei-Hua Gao Hao Li Chun-Hua Li Fang-Yao Chen Ke Gao Jie Zhang Robert Safirstein Feng Wang Tie-Lin Yang Jian-Jun Mu Jian-Jun Mu Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
| description |
Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk.Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension.Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 ± 1.1 vs. 34.7 ± 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972–0.984)] in Hanzhong Adolescent Hypertension Study cohort.Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension. |
| format |
article |
| author |
Yang Wang Yang Wang Ming-Fei Du Shi Yao Ting Zou Xiao-Yu Zhang Gui-Lin Hu Chao Chu Chao Chu Yue-Yuan Liao Yue-Yuan Liao Chen Chen Dan Wang Dan Wang Qiong Ma Qiong Ma Ke-Ke Wang Ke-Ke Wang Yue Sun Yue Sun Ze-Jiaxin Niu Ze-Jiaxin Niu Rui-Chen Yan Rui-Chen Yan Yu Yan Yu Yan Hao-Wei Zhou Hao Jia Wei-Hua Gao Hao Li Chun-Hua Li Fang-Yao Chen Ke Gao Jie Zhang Robert Safirstein Feng Wang Tie-Lin Yang Jian-Jun Mu Jian-Jun Mu |
| author_facet |
Yang Wang Yang Wang Ming-Fei Du Shi Yao Ting Zou Xiao-Yu Zhang Gui-Lin Hu Chao Chu Chao Chu Yue-Yuan Liao Yue-Yuan Liao Chen Chen Dan Wang Dan Wang Qiong Ma Qiong Ma Ke-Ke Wang Ke-Ke Wang Yue Sun Yue Sun Ze-Jiaxin Niu Ze-Jiaxin Niu Rui-Chen Yan Rui-Chen Yan Yu Yan Yu Yan Hao-Wei Zhou Hao Jia Wei-Hua Gao Hao Li Chun-Hua Li Fang-Yao Chen Ke Gao Jie Zhang Robert Safirstein Feng Wang Tie-Lin Yang Jian-Jun Mu Jian-Jun Mu |
| author_sort |
Yang Wang |
| title |
Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
| title_short |
Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
| title_full |
Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
| title_fullStr |
Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
| title_full_unstemmed |
Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
| title_sort |
associations of serum uromodulin and its genetic variants with blood pressure and hypertension in chinese adults |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/22c1c90570df4dbf91dba7f67b782e71 |
| work_keys_str_mv |
AT yangwang associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT yangwang associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT mingfeidu associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT shiyao associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT tingzou associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT xiaoyuzhang associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT guilinhu associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT chaochu associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT chaochu associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT yueyuanliao associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT yueyuanliao associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT chenchen associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT danwang associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT danwang associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT qiongma associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT qiongma associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT kekewang associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT kekewang associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT yuesun associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT yuesun associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT zejiaxinniu associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT zejiaxinniu associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT ruichenyan associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT ruichenyan associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT yuyan associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT yuyan associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT haoweizhou associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT haojia associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT weihuagao associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT haoli associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT chunhuali associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT fangyaochen associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT kegao associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT jiezhang associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT robertsafirstein associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT fengwang associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT tielinyang associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT jianjunmu associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults AT jianjunmu associationsofserumuromodulinanditsgeneticvariantswithbloodpressureandhypertensioninchineseadults |
| _version_ |
1718425911928291328 |