An Investigation of Selected Socio-Demographic Factors with Aplastic Anemia in Pakistan: A Case-Control Study

Muhammad Asif Syed,1 Aneela Atta Ur Rahman,2 Abdul Ghani,3 Muhammad Nadeem Shah Syed,4 Muhammad Ilyas Siddiqui,2 Hina Riaz,5 Feriha Fatima Khidri,6 Nayyar Nawaz Baloch1 1Field Epidemiology Laboratory Training Program (FELTP), Karachi, Pakistan; 2Department of Community Medicine & Public Heal...

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Autores principales:	Syed MA, Rahman AAU, Ghani A, Shah Syed MN, Siddiqui MI, Riaz H, Khidri FF, Baloch NN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	aplastic anemia socio-demographic factors case-control study pakistan Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/22c2cd2294e54c75becf08b711669a6e
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spelling	oai:doaj.org-article:22c2cd2294e54c75becf08b711669a6e2021-11-30T18:50:36ZAn Investigation of Selected Socio-Demographic Factors with Aplastic Anemia in Pakistan: A Case-Control Study1178-7074https://doaj.org/article/22c2cd2294e54c75becf08b711669a6e2021-11-01T00:00:00Zhttps://www.dovepress.com/an-investigation-of-selected-socio-demographic-factors-with-aplastic-a-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Muhammad Asif Syed,1 Aneela Atta Ur Rahman,2 Abdul Ghani,3 Muhammad Nadeem Shah Syed,4 Muhammad Ilyas Siddiqui,2 Hina Riaz,5 Feriha Fatima Khidri,6 Nayyar Nawaz Baloch1 1Field Epidemiology Laboratory Training Program (FELTP), Karachi, Pakistan; 2Department of Community Medicine & Public Health Sciences, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan; 3Department of Health, Jam Ghulam Qadir Government Teaching Hospital, Hub, Pakistan; 4National Emergency Operation Center, National Stop Transmission of Polio (N-STOP), Islamabad, Pakistan; 5Department of Physiology/Medical Research Centre, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan; 6Medical Research Centre, Bilawal Medical College, Jamshoro, PakistanCorrespondence: Muhammad Asif SyedField Epidemiology Laboratory Training Program (FELTP), Karachi, Sindh, PakistanTel +0092-333-286-34-77Email asif.mph@gmail.ccomIntroduction: In Pakistan, the incidence rate of aplastic anemia is 3.5 cases/million. The associated risk factors are exposure to pesticides, chemicals, and some drugs. The link between aplastic anemia and socio-demographic factors is debatable.Purpose: We conducted this study to investigate the role of socio-economic and -demographic factors with aplastic anemia.Methodology: A total of 191 lab-confirmed incident cases of aplastic anemia were identified from the tertiary hospital of Karachi-Pakistan in between 2015 and 2018. Age and gender-matched 694 controls were randomly selected from the same institute admitted or visited for other non-neoplastic conditions. Socio-demographic and exposure information was gathered using a data collection form. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were computed for selected socio-demographic factors.Results: Among socio-demographic factors, significant associations of aplastic anemia risk emerged for illiteracy (aOR: 2.3; 1.5; 3.5) occupation (any type) (aOR: 2.1; 1.7; 2.5), living in rural environments (aOR: 2.9; 1.9; 4.2). The odds of aplastic anemia increased with the age group 31– 50 years (aOR: 1.8; 1.7; 3.5) and > 50 years (aOR: 2.5; 2.1; 4.2). We observed no association of income with the risk of aplastic anemia.Conclusion: This study highlights the importance of socio-demographic factors as a risk factor for the development of aplastic anemia in the population of Pakistan. In order to reduce disease incidence, health education program and use of personal protective equipment and organization of screening camps in high-risk population is warranted.Keywords: aplastic anemia, Socio-demographic factors, case-control study, PakistanSyed MARahman AAUGhani AShah Syed MNSiddiqui MIRiaz HKhidri FFBaloch NNDove Medical Pressarticleaplastic anemiasocio-demographic factorscase-control studypakistanMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8929-8934 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aplastic anemia socio-demographic factors case-control study pakistan Medicine (General) R5-920
spellingShingle	aplastic anemia socio-demographic factors case-control study pakistan Medicine (General) R5-920 Syed MA Rahman AAU Ghani A Shah Syed MN Siddiqui MI Riaz H Khidri FF Baloch NN An Investigation of Selected Socio-Demographic Factors with Aplastic Anemia in Pakistan: A Case-Control Study
description	Muhammad Asif Syed,1 Aneela Atta Ur Rahman,2 Abdul Ghani,3 Muhammad Nadeem Shah Syed,4 Muhammad Ilyas Siddiqui,2 Hina Riaz,5 Feriha Fatima Khidri,6 Nayyar Nawaz Baloch1 1Field Epidemiology Laboratory Training Program (FELTP), Karachi, Pakistan; 2Department of Community Medicine & Public Health Sciences, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan; 3Department of Health, Jam Ghulam Qadir Government Teaching Hospital, Hub, Pakistan; 4National Emergency Operation Center, National Stop Transmission of Polio (N-STOP), Islamabad, Pakistan; 5Department of Physiology/Medical Research Centre, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan; 6Medical Research Centre, Bilawal Medical College, Jamshoro, PakistanCorrespondence: Muhammad Asif SyedField Epidemiology Laboratory Training Program (FELTP), Karachi, Sindh, PakistanTel +0092-333-286-34-77Email asif.mph@gmail.ccomIntroduction: In Pakistan, the incidence rate of aplastic anemia is 3.5 cases/million. The associated risk factors are exposure to pesticides, chemicals, and some drugs. The link between aplastic anemia and socio-demographic factors is debatable.Purpose: We conducted this study to investigate the role of socio-economic and -demographic factors with aplastic anemia.Methodology: A total of 191 lab-confirmed incident cases of aplastic anemia were identified from the tertiary hospital of Karachi-Pakistan in between 2015 and 2018. Age and gender-matched 694 controls were randomly selected from the same institute admitted or visited for other non-neoplastic conditions. Socio-demographic and exposure information was gathered using a data collection form. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were computed for selected socio-demographic factors.Results: Among socio-demographic factors, significant associations of aplastic anemia risk emerged for illiteracy (aOR: 2.3; 1.5; 3.5) occupation (any type) (aOR: 2.1; 1.7; 2.5), living in rural environments (aOR: 2.9; 1.9; 4.2). The odds of aplastic anemia increased with the age group 31– 50 years (aOR: 1.8; 1.7; 3.5) and > 50 years (aOR: 2.5; 2.1; 4.2). We observed no association of income with the risk of aplastic anemia.Conclusion: This study highlights the importance of socio-demographic factors as a risk factor for the development of aplastic anemia in the population of Pakistan. In order to reduce disease incidence, health education program and use of personal protective equipment and organization of screening camps in high-risk population is warranted.Keywords: aplastic anemia, Socio-demographic factors, case-control study, Pakistan
format	article
author	Syed MA Rahman AAU Ghani A Shah Syed MN Siddiqui MI Riaz H Khidri FF Baloch NN
author_facet	Syed MA Rahman AAU Ghani A Shah Syed MN Siddiqui MI Riaz H Khidri FF Baloch NN
author_sort	Syed MA
title	An Investigation of Selected Socio-Demographic Factors with Aplastic Anemia in Pakistan: A Case-Control Study
title_short	An Investigation of Selected Socio-Demographic Factors with Aplastic Anemia in Pakistan: A Case-Control Study
title_full	An Investigation of Selected Socio-Demographic Factors with Aplastic Anemia in Pakistan: A Case-Control Study
title_fullStr	An Investigation of Selected Socio-Demographic Factors with Aplastic Anemia in Pakistan: A Case-Control Study
title_full_unstemmed	An Investigation of Selected Socio-Demographic Factors with Aplastic Anemia in Pakistan: A Case-Control Study
title_sort	investigation of selected socio-demographic factors with aplastic anemia in pakistan: a case-control study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/22c2cd2294e54c75becf08b711669a6e
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An Investigation of Selected Socio-Demographic Factors with Aplastic Anemia in Pakistan: A Case-Control Study

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