Assessment of green and chemically synthesized copper oxide nanoparticles against hepatocellular carcinoma

Copper oxide nanoparticle (CuO-NPs) attracts the attentions of human beings due to unique physicochemical and biological properties. The chemical and green synthesis approaches were used to synthesis of CuO-NPs and plant leaves extract Azadirachta indica (A. indica) was preferred in green synthesis...

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Autores principales:	M. Fakhar-e-Alam, Zahra Shafiq, Arslan Mahmood, M. Atif, Hafeez Anwar, Atif Hanif, Nafeesah Yaqub, W.A. Farooq, Amanullah Fatehmulla, Shafiq Ahmad, Abd Elatty E. Abd Elgawad, K.S. Alimgeer, Tuan Nguyen Gia, Hijaz Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Chemical synthesis Green synthesis Anti-carcinoma activity Liver carcinoma Mathematical modeling Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/22c56f7497db4342a8673682f573cd6a
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spelling	oai:doaj.org-article:22c56f7497db4342a8673682f573cd6a2021-11-18T04:44:34ZAssessment of green and chemically synthesized copper oxide nanoparticles against hepatocellular carcinoma1018-364710.1016/j.jksus.2021.101669https://doaj.org/article/22c56f7497db4342a8673682f573cd6a2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003311https://doaj.org/toc/1018-3647Copper oxide nanoparticle (CuO-NPs) attracts the attentions of human beings due to unique physicochemical and biological properties. The chemical and green synthesis approaches were used to synthesis of CuO-NPs and plant leaves extract Azadirachta indica (A. indica) was preferred in green synthesis approach. The XRD analysis was used to analyze the monoclinic crystal structure and calculate the average crystallite size in the range of 15 ∼ 16 nm. While, the information about different rotational and vibrational modes attached on the spectrum of CuO-NPs was identified by FTIR. After that the UV–VIS analysis provided the information about the absorbance spectrums in the range of 235 and 220 nm. The MTT assay was perfomed to investigate liver carcinoma (HepG2 cells) interaction and absorbance of CuO-NPs towards mentioned cell lines were recorded and loss in HepG2 cells viability. In an overall assessment, anticancer response of comparative study of CuO-NPs towards liver carcinoma treatment contributes significantly after successful demonstration of essential steps of suggested experimental study. Finally, comparative study of experimental and mathematical modeling of anticancer activity towards normal and liver cancer cell lines were conducted and investigated.M. Fakhar-e-AlamZahra ShafiqArslan MahmoodM. AtifHafeez AnwarAtif HanifNafeesah YaqubW.A. FarooqAmanullah FatehmullaShafiq AhmadAbd Elatty E. Abd ElgawadK.S. AlimgeerTuan Nguyen GiaHijaz AhmedElsevierarticleChemical synthesisGreen synthesisAnti-carcinoma activityLiver carcinomaMathematical modelingScience (General)Q1-390ENJournal of King Saud University: Science, Vol 33, Iss 8, Pp 101669- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemical synthesis Green synthesis Anti-carcinoma activity Liver carcinoma Mathematical modeling Science (General) Q1-390
spellingShingle	Chemical synthesis Green synthesis Anti-carcinoma activity Liver carcinoma Mathematical modeling Science (General) Q1-390 M. Fakhar-e-Alam Zahra Shafiq Arslan Mahmood M. Atif Hafeez Anwar Atif Hanif Nafeesah Yaqub W.A. Farooq Amanullah Fatehmulla Shafiq Ahmad Abd Elatty E. Abd Elgawad K.S. Alimgeer Tuan Nguyen Gia Hijaz Ahmed Assessment of green and chemically synthesized copper oxide nanoparticles against hepatocellular carcinoma
description	Copper oxide nanoparticle (CuO-NPs) attracts the attentions of human beings due to unique physicochemical and biological properties. The chemical and green synthesis approaches were used to synthesis of CuO-NPs and plant leaves extract Azadirachta indica (A. indica) was preferred in green synthesis approach. The XRD analysis was used to analyze the monoclinic crystal structure and calculate the average crystallite size in the range of 15 ∼ 16 nm. While, the information about different rotational and vibrational modes attached on the spectrum of CuO-NPs was identified by FTIR. After that the UV–VIS analysis provided the information about the absorbance spectrums in the range of 235 and 220 nm. The MTT assay was perfomed to investigate liver carcinoma (HepG2 cells) interaction and absorbance of CuO-NPs towards mentioned cell lines were recorded and loss in HepG2 cells viability. In an overall assessment, anticancer response of comparative study of CuO-NPs towards liver carcinoma treatment contributes significantly after successful demonstration of essential steps of suggested experimental study. Finally, comparative study of experimental and mathematical modeling of anticancer activity towards normal and liver cancer cell lines were conducted and investigated.
format	article
author	M. Fakhar-e-Alam Zahra Shafiq Arslan Mahmood M. Atif Hafeez Anwar Atif Hanif Nafeesah Yaqub W.A. Farooq Amanullah Fatehmulla Shafiq Ahmad Abd Elatty E. Abd Elgawad K.S. Alimgeer Tuan Nguyen Gia Hijaz Ahmed
author_facet	M. Fakhar-e-Alam Zahra Shafiq Arslan Mahmood M. Atif Hafeez Anwar Atif Hanif Nafeesah Yaqub W.A. Farooq Amanullah Fatehmulla Shafiq Ahmad Abd Elatty E. Abd Elgawad K.S. Alimgeer Tuan Nguyen Gia Hijaz Ahmed
author_sort	M. Fakhar-e-Alam
title	Assessment of green and chemically synthesized copper oxide nanoparticles against hepatocellular carcinoma
title_short	Assessment of green and chemically synthesized copper oxide nanoparticles against hepatocellular carcinoma
title_full	Assessment of green and chemically synthesized copper oxide nanoparticles against hepatocellular carcinoma
title_fullStr	Assessment of green and chemically synthesized copper oxide nanoparticles against hepatocellular carcinoma
title_full_unstemmed	Assessment of green and chemically synthesized copper oxide nanoparticles against hepatocellular carcinoma
title_sort	assessment of green and chemically synthesized copper oxide nanoparticles against hepatocellular carcinoma
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/22c56f7497db4342a8673682f573cd6a
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Assessment of green and chemically synthesized copper oxide nanoparticles against hepatocellular carcinoma

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