Prophylactic intracameral levofloxacin in cataract surgery – an evaluation of safety

Prophylactic intracameral levofloxacin in cataract surgery – an evaluation of safety

Cesar Ramon G Espiritu,1,2,* Joanne G Bolinao1,* 1American Eye Center, Mandaluyong, 2Department of Ophthalmology, Manila Doctors Hospital, Manila, Philippines *The authors contributed equally to this work Purpose: To evaluate posterior and anterior segment safety of an intracameral injec...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Espiritu CR, Bolinao JG
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
intracameral levofloxacin
endophthalmitis prevention
phacoemulsification
cataract surgery
intraocular surgery
prophylaxis
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/22c58ef7057641e385072cc73d25008d
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:22c58ef7057641e385072cc73d25008d
record_format dspace
spelling oai:doaj.org-article:22c58ef7057641e385072cc73d25008d2021-12-02T07:38:57ZProphylactic intracameral levofloxacin in cataract surgery – an evaluation of safety1177-5483https://doaj.org/article/22c58ef7057641e385072cc73d25008d2017-12-01T00:00:00Zhttps://www.dovepress.com/prophylactic-intracameral-levofloxacin-in-cataract-surgery-an-evaluati-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Cesar Ramon G Espiritu,1,2,* Joanne G Bolinao1,* 1American Eye Center, Mandaluyong, 2Department of Ophthalmology, Manila Doctors Hospital, Manila, Philippines *The authors contributed equally to this work Purpose: To evaluate posterior and anterior segment safety of an intracameral injection of levofloxacin 0.5% ophthalmic solution as prophylaxis for patients undergoing cataract extraction and intraocular lens implantation.Setting: This study was conducted at Manila Doctors Hospital, Ermita, Manila, Philippines.Design: This was a prospective interventional study.Methods: Eyes undergoing standard phacoemulsification cataract surgery with intraocular lens implantation were treated with intracameral levofloxacin 0.5% at the conclusion of surgery. Safety parameters, including best-corrected visual acuity (BCVA), endothelial cell counts, anterior chamber cells and flare, and central foveal thickness, were evaluated preoperatively and at 1 day and 1 week postoperatively.Results: A total of 50 eyes of 50 patients were included in the analysis. At 1 week postoperatively, all eyes demonstrated BCVA of 20/30 or better and 19 eyes (38%) achieved BCVA of 20/20 or better. On the first postoperative day, no corneal edema was observed, and trace to +2 cells and flare in the anterior chamber were noted in all eyes. After 1 week, all eyes had a quiet anterior chamber and endothelial cell counts decreased by an average of 225 cells/mm2, which was marginally significant (p=0.0525) when compared to other time points. Optical coherence tomography results showed no statistically significant differences between central foveal thickness measurements before and after surgery. There were also no statistically significant differences in preoperative and postoperative pachymetry. No study-related adverse events occurred.Conclusion: There were no safety concerns associated with intracameral injection of levofloxacin 0.5%, prophylactically, following cataract surgery. Further study is required to demonstrate effectiveness in endophthalmitis prevention. Keywords: intracameral levofloxacin, endophthalmitis prevention, phacoemulsification, cataract surgery, intraocular surgery, prophylaxisEspiritu CRBolinao JGDove Medical Pressarticleintracameral levofloxacinendophthalmitis preventionphacoemulsificationcataract surgeryintraocular surgeryprophylaxisOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 2199-2204 (2017)
institution DOAJ
collection DOAJ
language EN
topic intracameral levofloxacin
endophthalmitis prevention
phacoemulsification
cataract surgery
intraocular surgery
prophylaxis
Ophthalmology
RE1-994
spellingShingle intracameral levofloxacin
endophthalmitis prevention
phacoemulsification
cataract surgery
intraocular surgery
prophylaxis
Ophthalmology
RE1-994
Espiritu CR
Bolinao JG
Prophylactic intracameral levofloxacin in cataract surgery – an evaluation of safety
description Cesar Ramon G Espiritu,1,2,* Joanne G Bolinao1,* 1American Eye Center, Mandaluyong, 2Department of Ophthalmology, Manila Doctors Hospital, Manila, Philippines *The authors contributed equally to this work Purpose: To evaluate posterior and anterior segment safety of an intracameral injection of levofloxacin 0.5% ophthalmic solution as prophylaxis for patients undergoing cataract extraction and intraocular lens implantation.Setting: This study was conducted at Manila Doctors Hospital, Ermita, Manila, Philippines.Design: This was a prospective interventional study.Methods: Eyes undergoing standard phacoemulsification cataract surgery with intraocular lens implantation were treated with intracameral levofloxacin 0.5% at the conclusion of surgery. Safety parameters, including best-corrected visual acuity (BCVA), endothelial cell counts, anterior chamber cells and flare, and central foveal thickness, were evaluated preoperatively and at 1 day and 1 week postoperatively.Results: A total of 50 eyes of 50 patients were included in the analysis. At 1 week postoperatively, all eyes demonstrated BCVA of 20/30 or better and 19 eyes (38%) achieved BCVA of 20/20 or better. On the first postoperative day, no corneal edema was observed, and trace to +2 cells and flare in the anterior chamber were noted in all eyes. After 1 week, all eyes had a quiet anterior chamber and endothelial cell counts decreased by an average of 225 cells/mm2, which was marginally significant (p=0.0525) when compared to other time points. Optical coherence tomography results showed no statistically significant differences between central foveal thickness measurements before and after surgery. There were also no statistically significant differences in preoperative and postoperative pachymetry. No study-related adverse events occurred.Conclusion: There were no safety concerns associated with intracameral injection of levofloxacin 0.5%, prophylactically, following cataract surgery. Further study is required to demonstrate effectiveness in endophthalmitis prevention. Keywords: intracameral levofloxacin, endophthalmitis prevention, phacoemulsification, cataract surgery, intraocular surgery, prophylaxis
format article
author Espiritu CR
Bolinao JG
author_facet Espiritu CR
Bolinao JG
author_sort Espiritu CR
title Prophylactic intracameral levofloxacin in cataract surgery – an evaluation of safety
title_short Prophylactic intracameral levofloxacin in cataract surgery – an evaluation of safety
title_full Prophylactic intracameral levofloxacin in cataract surgery – an evaluation of safety
title_fullStr Prophylactic intracameral levofloxacin in cataract surgery – an evaluation of safety
title_full_unstemmed Prophylactic intracameral levofloxacin in cataract surgery – an evaluation of safety
title_sort prophylactic intracameral levofloxacin in cataract surgery – an evaluation of safety
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/22c58ef7057641e385072cc73d25008d
work_keys_str_mv AT espiritucr prophylacticintracamerallevofloxacinincataractsurgeryndashanevaluationofsafety
AT bolinaojg prophylacticintracamerallevofloxacinincataractsurgeryndashanevaluationofsafety
_version_ 1718399268854693888

Ejemplares similares