Effect of intra-hippocampal lead injection on affective and cognitive disorders in male WISTAR rats: Possible involvement of oxidative stress

This paper is focused on affective and cognitive disorders induced by direct exposure to lead chloride (Pb) and the possible implication of oxidative stress in male WISTAR rats. Using stereotaxic surgery, a group of male wistar rats received an intracerebral injection of 3 μL of lead chloride (1 mg...

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Autores principales:	Naïla Nakidi, Makthar War, Lamtai Mouloud, Zghari Oussama, Aboubaker El Hessni, Abdelhalem Mesfioui, Ali Ouichou
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	depression anxiety oxidative stress chloride lead short-term memory spatial memory wistar rats Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/22c8e2aac29542eb84ca5d3bbdeaca46
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spelling	oai:doaj.org-article:22c8e2aac29542eb84ca5d3bbdeaca462021-12-02T17:11:26ZEffect of intra-hippocampal lead injection on affective and cognitive disorders in male WISTAR rats: Possible involvement of oxidative stress2267-124210.1051/e3sconf/202131902017https://doaj.org/article/22c8e2aac29542eb84ca5d3bbdeaca462021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/95/e3sconf_vigisan_02017.pdfhttps://doaj.org/toc/2267-1242This paper is focused on affective and cognitive disorders induced by direct exposure to lead chloride (Pb) and the possible implication of oxidative stress in male WISTAR rats. Using stereotaxic surgery, a group of male wistar rats received an intracerebral injection of 3 μL of lead chloride (1 mg / L) into the right hippocampus or 3 μL of 0.9% Nacl for shame operated controls groups. After 4 days of rest, a series of benchmark neurobehavioral tests were made to evaluate affective and cognitive behaviors, such as open field test (OFT) and Elevated plus maze (EPM) for anxiety like behavior; Forced swim test (FST) for depressive like behavior; finally Y maze (Y-Maze) and Morris maze (MWM) tests for working memory, spatial learning and spatial memory. The data showed that Pb induces anxiogenic and depressogenic effects but does not induce a significant effect in memory. Then by measuring oxidative stress markers using the hippocampal assay of lead-treated rats, it’s appears that Pb can increase nitrogen monoxide, lipid peroxidation and reduces significantly the activity of superoxide dismutase. Therefore, our results showed that Pb is able to induce affective disorders and increase highly oxidative stress but has an insignificant effect on cognitive impairment.Naïla NakidiMakthar WarLamtai MouloudZghari OussamaAboubaker El HessniAbdelhalem MesfiouiAli OuichouEDP Sciencesarticledepressionanxietyoxidative stresschloride leadshort-term memoryspatial memorywistar ratsEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 319, p 02017 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	depression anxiety oxidative stress chloride lead short-term memory spatial memory wistar rats Environmental sciences GE1-350
spellingShingle	depression anxiety oxidative stress chloride lead short-term memory spatial memory wistar rats Environmental sciences GE1-350 Naïla Nakidi Makthar War Lamtai Mouloud Zghari Oussama Aboubaker El Hessni Abdelhalem Mesfioui Ali Ouichou Effect of intra-hippocampal lead injection on affective and cognitive disorders in male WISTAR rats: Possible involvement of oxidative stress
description	This paper is focused on affective and cognitive disorders induced by direct exposure to lead chloride (Pb) and the possible implication of oxidative stress in male WISTAR rats. Using stereotaxic surgery, a group of male wistar rats received an intracerebral injection of 3 μL of lead chloride (1 mg / L) into the right hippocampus or 3 μL of 0.9% Nacl for shame operated controls groups. After 4 days of rest, a series of benchmark neurobehavioral tests were made to evaluate affective and cognitive behaviors, such as open field test (OFT) and Elevated plus maze (EPM) for anxiety like behavior; Forced swim test (FST) for depressive like behavior; finally Y maze (Y-Maze) and Morris maze (MWM) tests for working memory, spatial learning and spatial memory. The data showed that Pb induces anxiogenic and depressogenic effects but does not induce a significant effect in memory. Then by measuring oxidative stress markers using the hippocampal assay of lead-treated rats, it’s appears that Pb can increase nitrogen monoxide, lipid peroxidation and reduces significantly the activity of superoxide dismutase. Therefore, our results showed that Pb is able to induce affective disorders and increase highly oxidative stress but has an insignificant effect on cognitive impairment.
format	article
author	Naïla Nakidi Makthar War Lamtai Mouloud Zghari Oussama Aboubaker El Hessni Abdelhalem Mesfioui Ali Ouichou
author_facet	Naïla Nakidi Makthar War Lamtai Mouloud Zghari Oussama Aboubaker El Hessni Abdelhalem Mesfioui Ali Ouichou
author_sort	Naïla Nakidi
title	Effect of intra-hippocampal lead injection on affective and cognitive disorders in male WISTAR rats: Possible involvement of oxidative stress
title_short	Effect of intra-hippocampal lead injection on affective and cognitive disorders in male WISTAR rats: Possible involvement of oxidative stress
title_full	Effect of intra-hippocampal lead injection on affective and cognitive disorders in male WISTAR rats: Possible involvement of oxidative stress
title_fullStr	Effect of intra-hippocampal lead injection on affective and cognitive disorders in male WISTAR rats: Possible involvement of oxidative stress
title_full_unstemmed	Effect of intra-hippocampal lead injection on affective and cognitive disorders in male WISTAR rats: Possible involvement of oxidative stress
title_sort	effect of intra-hippocampal lead injection on affective and cognitive disorders in male wistar rats: possible involvement of oxidative stress
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/22c8e2aac29542eb84ca5d3bbdeaca46
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Effect of intra-hippocampal lead injection on affective and cognitive disorders in male WISTAR rats: Possible involvement of oxidative stress

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