Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The incidence of hepatocellular carcinoma (HCC) is increasing in the United States, and chronic, excessive alcohol consumption is responsible for 32%–45% of all the liver cancer cases in the United States. Avoidance...

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Autores principales:	Camilla P. Stice, Hui Xia, Xiang-Dong Wang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/22ca99d50bc34d748dc400dd68c88ecf
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spelling	oai:doaj.org-article:22ca99d50bc34d748dc400dd68c88ecf2021-12-02T11:53:35ZTomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development2095-882X10.1016/j.cdtm.2018.11.001https://doaj.org/article/22ca99d50bc34d748dc400dd68c88ecf2018-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X18300665https://doaj.org/toc/2095-882XAlcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The incidence of hepatocellular carcinoma (HCC) is increasing in the United States, and chronic, excessive alcohol consumption is responsible for 32%–45% of all the liver cancer cases in the United States. Avoidance of chronic or excessive alcohol intake is the best protection against alcohol-related liver injury; however, the social presence and addictive power of alcohol are strong. Induction of the cytochrome P450 2E1 (CYP2E1) enzyme by chronic and excessive alcohol intake is known to play a role in the pathogenesis of ALD. High intake of tomatoes, rich in the carotenoid lycopene, is associated with a decreased risk of chronic disease. The review will overview the prevention of ALD and HCC through dietary tomato rich in lycopene as an effective intervention strategy and the crucial role of CYP2E1 induction as a molecular target. The review also indicates a need for caution among individuals consuming both alcohol and high dose lycopene as a dietary supplement. Keywords: Tomato, Lycopene, Alcoholic liver disease, Liver cancer, CYP2E1Camilla P. SticeHui XiaXiang-Dong WangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 4, Iss 4, Pp 211-224 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Camilla P. Stice Hui Xia Xiang-Dong Wang Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development
description	Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The incidence of hepatocellular carcinoma (HCC) is increasing in the United States, and chronic, excessive alcohol consumption is responsible for 32%–45% of all the liver cancer cases in the United States. Avoidance of chronic or excessive alcohol intake is the best protection against alcohol-related liver injury; however, the social presence and addictive power of alcohol are strong. Induction of the cytochrome P450 2E1 (CYP2E1) enzyme by chronic and excessive alcohol intake is known to play a role in the pathogenesis of ALD. High intake of tomatoes, rich in the carotenoid lycopene, is associated with a decreased risk of chronic disease. The review will overview the prevention of ALD and HCC through dietary tomato rich in lycopene as an effective intervention strategy and the crucial role of CYP2E1 induction as a molecular target. The review also indicates a need for caution among individuals consuming both alcohol and high dose lycopene as a dietary supplement. Keywords: Tomato, Lycopene, Alcoholic liver disease, Liver cancer, CYP2E1
format	article
author	Camilla P. Stice Hui Xia Xiang-Dong Wang
author_facet	Camilla P. Stice Hui Xia Xiang-Dong Wang
author_sort	Camilla P. Stice
title	Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development
title_short	Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development
title_full	Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development
title_fullStr	Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development
title_full_unstemmed	Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development
title_sort	tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/22ca99d50bc34d748dc400dd68c88ecf
work_keys_str_mv	AT camillapstice tomatolycopenepreventionofalcoholicfattyliverdiseaseandhepatocellularcarcinomadevelopment AT huixia tomatolycopenepreventionofalcoholicfattyliverdiseaseandhepatocellularcarcinomadevelopment AT xiangdongwang tomatolycopenepreventionofalcoholicfattyliverdiseaseandhepatocellularcarcinomadevelopment
_version_	1718394795017109504

Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

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