Adipose tissue fatty acid patterns and changes in anthropometry: a cohort study.

<h4>Introduction</h4>Diets rich in n-3 long chain polyunsaturated fatty acids (LC-PUFA), but low in n-6 LC-PUFA and 18:1 trans-fatty acids (TFA), may lower the risk of overweight and obesity. These fatty acids have often been investigated individually. We explored associations between gl...

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Autores principales:	Christina Catherine Dahm, Anders Gorst-Rasmussen, Marianne Uhre Jakobsen, Erik Berg Schmidt, Anne Tjønneland, Thorkild I A Sørensen, Kim Overvad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22ce46b85ed04979ab86f6794cc4e83c
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spelling	oai:doaj.org-article:22ce46b85ed04979ab86f6794cc4e83c2021-11-18T06:49:44ZAdipose tissue fatty acid patterns and changes in anthropometry: a cohort study.1932-620310.1371/journal.pone.0022587https://doaj.org/article/22ce46b85ed04979ab86f6794cc4e83c2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21811635/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Diets rich in n-3 long chain polyunsaturated fatty acids (LC-PUFA), but low in n-6 LC-PUFA and 18:1 trans-fatty acids (TFA), may lower the risk of overweight and obesity. These fatty acids have often been investigated individually. We explored associations between global patterns in adipose tissue fatty acids and changes in anthropometry.<h4>Methods</h4>34 fatty acid species from adipose tissue biopsies were determined in a random sample of 1100 men and women from a Danish cohort study. We used sex-specific principal component analysis and multiple linear regression to investigate the associations of adipose tissue fatty acid patterns with changes in weight, waist circumference (WC), and WC controlled for changes in body mass index (WC(BMI)), adjusting for confounders.<h4>Results</h4>7 principal components were extracted for each sex, explaining 77.6% and 78.3% of fatty acid variation in men and women, respectively. Fatty acid patterns with high levels of TFA tended to be positively associated with changes in weight and WC for both sexes. Patterns with high levels of n-6 LC-PUFA tended to be negatively associated with changes in weight and WC in men, and positively associated in women. Associations with patterns with high levels of n-3 LC-PUFA were dependent on the context of the rest of the fatty acid pattern.<h4>Conclusions</h4>Adipose tissue fatty acid patterns with high levels of TFA may be linked to weight gain, but patterns with high n-3 LC-PUFA did not appear to be linked to weight loss. Associations depended on characteristics of the rest of the pattern.Christina Catherine DahmAnders Gorst-RasmussenMarianne Uhre JakobsenErik Berg SchmidtAnne TjønnelandThorkild I A SørensenKim OvervadPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22587 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christina Catherine Dahm Anders Gorst-Rasmussen Marianne Uhre Jakobsen Erik Berg Schmidt Anne Tjønneland Thorkild I A Sørensen Kim Overvad Adipose tissue fatty acid patterns and changes in anthropometry: a cohort study.
description	<h4>Introduction</h4>Diets rich in n-3 long chain polyunsaturated fatty acids (LC-PUFA), but low in n-6 LC-PUFA and 18:1 trans-fatty acids (TFA), may lower the risk of overweight and obesity. These fatty acids have often been investigated individually. We explored associations between global patterns in adipose tissue fatty acids and changes in anthropometry.<h4>Methods</h4>34 fatty acid species from adipose tissue biopsies were determined in a random sample of 1100 men and women from a Danish cohort study. We used sex-specific principal component analysis and multiple linear regression to investigate the associations of adipose tissue fatty acid patterns with changes in weight, waist circumference (WC), and WC controlled for changes in body mass index (WC(BMI)), adjusting for confounders.<h4>Results</h4>7 principal components were extracted for each sex, explaining 77.6% and 78.3% of fatty acid variation in men and women, respectively. Fatty acid patterns with high levels of TFA tended to be positively associated with changes in weight and WC for both sexes. Patterns with high levels of n-6 LC-PUFA tended to be negatively associated with changes in weight and WC in men, and positively associated in women. Associations with patterns with high levels of n-3 LC-PUFA were dependent on the context of the rest of the fatty acid pattern.<h4>Conclusions</h4>Adipose tissue fatty acid patterns with high levels of TFA may be linked to weight gain, but patterns with high n-3 LC-PUFA did not appear to be linked to weight loss. Associations depended on characteristics of the rest of the pattern.
format	article
author	Christina Catherine Dahm Anders Gorst-Rasmussen Marianne Uhre Jakobsen Erik Berg Schmidt Anne Tjønneland Thorkild I A Sørensen Kim Overvad
author_facet	Christina Catherine Dahm Anders Gorst-Rasmussen Marianne Uhre Jakobsen Erik Berg Schmidt Anne Tjønneland Thorkild I A Sørensen Kim Overvad
author_sort	Christina Catherine Dahm
title	Adipose tissue fatty acid patterns and changes in anthropometry: a cohort study.
title_short	Adipose tissue fatty acid patterns and changes in anthropometry: a cohort study.
title_full	Adipose tissue fatty acid patterns and changes in anthropometry: a cohort study.
title_fullStr	Adipose tissue fatty acid patterns and changes in anthropometry: a cohort study.
title_full_unstemmed	Adipose tissue fatty acid patterns and changes in anthropometry: a cohort study.
title_sort	adipose tissue fatty acid patterns and changes in anthropometry: a cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/22ce46b85ed04979ab86f6794cc4e83c
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Adipose tissue fatty acid patterns and changes in anthropometry: a cohort study.

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