Does eating less make you live longer and better? An update on calorie restriction

Anna Picca,1 Vito Pesce,2 Angela Maria Serena Lezza2 1Department of Geriatrics, Neuroscience and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome, 2Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy Abstract: The complexity...

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Autores principales:	Picca A, Pesce V, Lezza AMS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	aging calorie restriction studies on humans CR molecular mechanisms CR mimetics. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/22d0886aa06b49fca6760a4684670a48
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spelling	oai:doaj.org-article:22d0886aa06b49fca6760a4684670a482021-12-02T00:53:59ZDoes eating less make you live longer and better? An update on calorie restriction1178-1998https://doaj.org/article/22d0886aa06b49fca6760a4684670a482017-11-01T00:00:00Zhttps://www.dovepress.com/does-eating-less-make-you-live-longer-and-better-an-update-on-calorie--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Anna Picca,1 Vito Pesce,2 Angela Maria Serena Lezza2 1Department of Geriatrics, Neuroscience and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome, 2Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy Abstract: The complexity of aging is hard to be captured. However, apart from its tissue-specific features, a structural and functional progressive decline of the whole organism that leads to death, often preceded by a phase of chronic morbidity, characterizes the common process of aging. Therefore, the research goal of scientists in the field moved from the search for strategies able to extend longevity to those ensuring healthy aging associated with a longer lifespan referred to as “healthspan”. The aging process is plastic and can be tuned by multiple mechanisms including dietary and genetic interventions. To date, the most robust approach, efficient in warding off the cellular markers of aging, is calorie restriction (CR). Here, after a preliminary presentation of the major debate originated by CR, we concisely overviewed the recent results of CR treatment on humans. We also provided an update on the molecular mechanisms involved by CR and the effects on some of the age-associated cellular markers. We finally reviewed a number of tested CR mimetics and concluded with an evaluation of future applications of such dietary approach. Keywords: aging, calorie restriction, studies on humans, CR molecular mechanisms, CR mimeticsPicca APesce VLezza AMSDove Medical Pressarticleagingcalorie restrictionstudies on humansCR molecular mechanismsCR mimetics.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1887-1902 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging calorie restriction studies on humans CR molecular mechanisms CR mimetics. Geriatrics RC952-954.6
spellingShingle	aging calorie restriction studies on humans CR molecular mechanisms CR mimetics. Geriatrics RC952-954.6 Picca A Pesce V Lezza AMS Does eating less make you live longer and better? An update on calorie restriction
description	Anna Picca,1 Vito Pesce,2 Angela Maria Serena Lezza2 1Department of Geriatrics, Neuroscience and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome, 2Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy Abstract: The complexity of aging is hard to be captured. However, apart from its tissue-specific features, a structural and functional progressive decline of the whole organism that leads to death, often preceded by a phase of chronic morbidity, characterizes the common process of aging. Therefore, the research goal of scientists in the field moved from the search for strategies able to extend longevity to those ensuring healthy aging associated with a longer lifespan referred to as “healthspan”. The aging process is plastic and can be tuned by multiple mechanisms including dietary and genetic interventions. To date, the most robust approach, efficient in warding off the cellular markers of aging, is calorie restriction (CR). Here, after a preliminary presentation of the major debate originated by CR, we concisely overviewed the recent results of CR treatment on humans. We also provided an update on the molecular mechanisms involved by CR and the effects on some of the age-associated cellular markers. We finally reviewed a number of tested CR mimetics and concluded with an evaluation of future applications of such dietary approach. Keywords: aging, calorie restriction, studies on humans, CR molecular mechanisms, CR mimetics
format	article
author	Picca A Pesce V Lezza AMS
author_facet	Picca A Pesce V Lezza AMS
author_sort	Picca A
title	Does eating less make you live longer and better? An update on calorie restriction
title_short	Does eating less make you live longer and better? An update on calorie restriction
title_full	Does eating less make you live longer and better? An update on calorie restriction
title_fullStr	Does eating less make you live longer and better? An update on calorie restriction
title_full_unstemmed	Does eating less make you live longer and better? An update on calorie restriction
title_sort	does eating less make you live longer and better? an update on calorie restriction
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/22d0886aa06b49fca6760a4684670a48
work_keys_str_mv	AT piccaa doeseatinglessmakeyoulivelongerandbetteranupdateoncalorierestriction AT pescev doeseatinglessmakeyoulivelongerandbetteranupdateoncalorierestriction AT lezzaams doeseatinglessmakeyoulivelongerandbetteranupdateoncalorierestriction
_version_	1718403425812611072

Does eating less make you live longer and better? An update on calorie restriction

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