CRISPR-based genome editing in primary human pancreatic islet cells

The editing of primary human islets could provide insight into diabetes pathogenesis. Here the authors use CRISPR-Cas9 to target regulatory elements associated with T2D susceptibility.

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Detalles Bibliográficos
Autores principales:	Romina J. Bevacqua, Xiaoqing Dai, Jonathan Y. Lam, Xueying Gu, Mollie S. H. Friedlander, Krissie Tellez, Irene Miguel-Escalada, Silvia Bonàs-Guarch, Goutham Atla, Weichen Zhao, Seung Hyun Kim, Antonia A. Dominguez, Lei S. Qi, Jorge Ferrer, Patrick E. MacDonald, Seung K. Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22d2b0339efc4aa29c30bb51db113c85
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spelling	oai:doaj.org-article:22d2b0339efc4aa29c30bb51db113c852021-12-02T17:33:40ZCRISPR-based genome editing in primary human pancreatic islet cells10.1038/s41467-021-22651-w2041-1723https://doaj.org/article/22d2b0339efc4aa29c30bb51db113c852021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22651-whttps://doaj.org/toc/2041-1723The editing of primary human islets could provide insight into diabetes pathogenesis. Here the authors use CRISPR-Cas9 to target regulatory elements associated with T2D susceptibility.Romina J. BevacquaXiaoqing DaiJonathan Y. LamXueying GuMollie S. H. FriedlanderKrissie TellezIrene Miguel-EscaladaSilvia Bonàs-GuarchGoutham AtlaWeichen ZhaoSeung Hyun KimAntonia A. DominguezLei S. QiJorge FerrerPatrick E. MacDonaldSeung K. KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Romina J. Bevacqua Xiaoqing Dai Jonathan Y. Lam Xueying Gu Mollie S. H. Friedlander Krissie Tellez Irene Miguel-Escalada Silvia Bonàs-Guarch Goutham Atla Weichen Zhao Seung Hyun Kim Antonia A. Dominguez Lei S. Qi Jorge Ferrer Patrick E. MacDonald Seung K. Kim CRISPR-based genome editing in primary human pancreatic islet cells
description	The editing of primary human islets could provide insight into diabetes pathogenesis. Here the authors use CRISPR-Cas9 to target regulatory elements associated with T2D susceptibility.
format	article
author	Romina J. Bevacqua Xiaoqing Dai Jonathan Y. Lam Xueying Gu Mollie S. H. Friedlander Krissie Tellez Irene Miguel-Escalada Silvia Bonàs-Guarch Goutham Atla Weichen Zhao Seung Hyun Kim Antonia A. Dominguez Lei S. Qi Jorge Ferrer Patrick E. MacDonald Seung K. Kim
author_facet	Romina J. Bevacqua Xiaoqing Dai Jonathan Y. Lam Xueying Gu Mollie S. H. Friedlander Krissie Tellez Irene Miguel-Escalada Silvia Bonàs-Guarch Goutham Atla Weichen Zhao Seung Hyun Kim Antonia A. Dominguez Lei S. Qi Jorge Ferrer Patrick E. MacDonald Seung K. Kim
author_sort	Romina J. Bevacqua
title	CRISPR-based genome editing in primary human pancreatic islet cells
title_short	CRISPR-based genome editing in primary human pancreatic islet cells
title_full	CRISPR-based genome editing in primary human pancreatic islet cells
title_fullStr	CRISPR-based genome editing in primary human pancreatic islet cells
title_full_unstemmed	CRISPR-based genome editing in primary human pancreatic islet cells
title_sort	crispr-based genome editing in primary human pancreatic islet cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/22d2b0339efc4aa29c30bb51db113c85
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CRISPR-based genome editing in primary human pancreatic islet cells

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