Formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac

Malahat Rezaee,1 Mahiran Basri,1,2 Raja Noor Zaliha Raja Abdul Rahman,3 Abu Bakar Salleh,3 Naz Chaibakhsh,4 Roghayeh Abedi Karjiban21Institute of Bioscience, 2Faculty of Science, 3Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 4Faculty of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rezaee M, Basri M, Rahman RNZRA, Salleh AB, Chaibakhsh N, Abedi Karjiban R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/22d44580d05e4fe4966bdf62d2d769dc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:22d44580d05e4fe4966bdf62d2d769dc
record_format	dspace
spelling	oai:doaj.org-article:22d44580d05e4fe4966bdf62d2d769dc2021-12-02T02:10:21ZFormulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac1178-2013https://doaj.org/article/22d44580d05e4fe4966bdf62d2d769dc2014-01-01T00:00:00Zhttp://www.dovepress.com/formulation-development-and-optimization-of-palm-kernel-oil-esters-bas-a15551https://doaj.org/toc/1178-2013 Malahat Rezaee,1 Mahiran Basri,1,2 Raja Noor Zaliha Raja Abdul Rahman,3 Abu Bakar Salleh,3 Naz Chaibakhsh,4 Roghayeh Abedi Karjiban21Institute of Bioscience, 2Faculty of Science, 3Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 4Faculty of Science, University of Guilan, Rasht, IranAbstract: Response surface methodology was employed to study the effect of formulation composition variables, water content (60%–80%, w/w) and oil and surfactant (O/S) ratio (0.17–1.33), as well as high-shear emulsification conditions, mixing rate (300–3,000 rpm) and mixing time (5–30 minutes) on the properties of sodium diclofenac-loaded palm kernel oil esters-nanoemulsions. The two response variables were droplet size and viscosity. Optimization of the conditions according to the four variables was performed for preparation of the nanoemulsions with the minimum values of particle size and viscosity. The results showed that the experimental data could be sufficiently fitted into a third-order polynomial model with multiple regression coefficients (R2) of 0.938 and 0.994 for the particle size and viscosity, respectively. Water content, O/S ratio and mixing time, quadrics of all independent variables, interaction between O/S ratio and mixing rate and between mixing time and rate, as well as cubic term of water content had a significant effect (P<0.05) on the particle size of nanoemulsions. The linear effect of all independent variables, quadrics of water content and O/S ratio, interaction of water content and O/S ratio, as well as cubic term of water content and O/S ratio had significant effects (P<0.05) on the viscosity of all nanoemulsions. The optimum conditions for preparation of sodium diclofenac nanoemulsions were predicted to be: 71.36% water content; 0.69 O/S ratio; 950 rpm mixing rate, and 5 minute mixing time. The optimized formulation showed good storage stability in different temperatures.Keywords: response surface methodology, nanoemulsions, palm kernel oil esters, optimization, particle size, viscosityRezaee MBasri MRahman RNZRASalleh ABChaibakhsh NAbedi Karjiban RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 539-548 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Rezaee M Basri M Rahman RNZRA Salleh AB Chaibakhsh N Abedi Karjiban R Formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac
description	Malahat Rezaee,1 Mahiran Basri,1,2 Raja Noor Zaliha Raja Abdul Rahman,3 Abu Bakar Salleh,3 Naz Chaibakhsh,4 Roghayeh Abedi Karjiban21Institute of Bioscience, 2Faculty of Science, 3Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 4Faculty of Science, University of Guilan, Rasht, IranAbstract: Response surface methodology was employed to study the effect of formulation composition variables, water content (60%–80%, w/w) and oil and surfactant (O/S) ratio (0.17–1.33), as well as high-shear emulsification conditions, mixing rate (300–3,000 rpm) and mixing time (5–30 minutes) on the properties of sodium diclofenac-loaded palm kernel oil esters-nanoemulsions. The two response variables were droplet size and viscosity. Optimization of the conditions according to the four variables was performed for preparation of the nanoemulsions with the minimum values of particle size and viscosity. The results showed that the experimental data could be sufficiently fitted into a third-order polynomial model with multiple regression coefficients (R2) of 0.938 and 0.994 for the particle size and viscosity, respectively. Water content, O/S ratio and mixing time, quadrics of all independent variables, interaction between O/S ratio and mixing rate and between mixing time and rate, as well as cubic term of water content had a significant effect (P<0.05) on the particle size of nanoemulsions. The linear effect of all independent variables, quadrics of water content and O/S ratio, interaction of water content and O/S ratio, as well as cubic term of water content and O/S ratio had significant effects (P<0.05) on the viscosity of all nanoemulsions. The optimum conditions for preparation of sodium diclofenac nanoemulsions were predicted to be: 71.36% water content; 0.69 O/S ratio; 950 rpm mixing rate, and 5 minute mixing time. The optimized formulation showed good storage stability in different temperatures.Keywords: response surface methodology, nanoemulsions, palm kernel oil esters, optimization, particle size, viscosity
format	article
author	Rezaee M Basri M Rahman RNZRA Salleh AB Chaibakhsh N Abedi Karjiban R
author_facet	Rezaee M Basri M Rahman RNZRA Salleh AB Chaibakhsh N Abedi Karjiban R
author_sort	Rezaee M
title	Formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac
title_short	Formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac
title_full	Formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac
title_fullStr	Formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac
title_full_unstemmed	Formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac
title_sort	formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/22d44580d05e4fe4966bdf62d2d769dc
work_keys_str_mv	AT rezaeem formulationdevelopmentandoptimizationofpalmkerneloilestersbasednanoemulsionscontainingsodiumdiclofenac AT basrim formulationdevelopmentandoptimizationofpalmkerneloilestersbasednanoemulsionscontainingsodiumdiclofenac AT rahmanrnzra formulationdevelopmentandoptimizationofpalmkerneloilestersbasednanoemulsionscontainingsodiumdiclofenac AT sallehab formulationdevelopmentandoptimizationofpalmkerneloilestersbasednanoemulsionscontainingsodiumdiclofenac AT chaibakhshn formulationdevelopmentandoptimizationofpalmkerneloilestersbasednanoemulsionscontainingsodiumdiclofenac AT abedikarjibanr formulationdevelopmentandoptimizationofpalmkerneloilestersbasednanoemulsionscontainingsodiumdiclofenac
_version_	1718402637181747200

Formulation development and optimization of palm kernel oil esters-based nanoemulsions containing sodium diclofenac

Ejemplares similares