Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor

The molecular chaperone Hsp90 oversees the folding of many proteins associated with cancer progression but existing small-molecule inhibitors of this pathway are not isoform-selective. Here, the authors rationally design an Hsp90 inhibitor that displays high selectivity for the Hsp90β isoform.

Guardado en:

Detalles Bibliográficos
Autores principales:	Anuj Khandelwal, Caitlin N. Kent, Maurie Balch, Shuxia Peng, Sanket J. Mishra, Junpeng Deng, Victor W. Day, Weiya Liu, Chitra Subramanian, Mark Cohen, Jeffery M. Holzbeierlein, Robert Matts, Brian S. J. Blagg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22d6d57dbf0548efa5ef84106a4676a4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:22d6d57dbf0548efa5ef84106a4676a4
record_format	dspace
spelling	oai:doaj.org-article:22d6d57dbf0548efa5ef84106a4676a42021-12-02T16:49:38ZStructure-guided design of an Hsp90β N-terminal isoform-selective inhibitor10.1038/s41467-017-02013-12041-1723https://doaj.org/article/22d6d57dbf0548efa5ef84106a4676a42018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02013-1https://doaj.org/toc/2041-1723The molecular chaperone Hsp90 oversees the folding of many proteins associated with cancer progression but existing small-molecule inhibitors of this pathway are not isoform-selective. Here, the authors rationally design an Hsp90 inhibitor that displays high selectivity for the Hsp90β isoform.Anuj KhandelwalCaitlin N. KentMaurie BalchShuxia PengSanket J. MishraJunpeng DengVictor W. DayWeiya LiuChitra SubramanianMark CohenJeffery M. HolzbeierleinRobert MattsBrian S. J. BlaggNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anuj Khandelwal Caitlin N. Kent Maurie Balch Shuxia Peng Sanket J. Mishra Junpeng Deng Victor W. Day Weiya Liu Chitra Subramanian Mark Cohen Jeffery M. Holzbeierlein Robert Matts Brian S. J. Blagg Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
description	The molecular chaperone Hsp90 oversees the folding of many proteins associated with cancer progression but existing small-molecule inhibitors of this pathway are not isoform-selective. Here, the authors rationally design an Hsp90 inhibitor that displays high selectivity for the Hsp90β isoform.
format	article
author	Anuj Khandelwal Caitlin N. Kent Maurie Balch Shuxia Peng Sanket J. Mishra Junpeng Deng Victor W. Day Weiya Liu Chitra Subramanian Mark Cohen Jeffery M. Holzbeierlein Robert Matts Brian S. J. Blagg
author_facet	Anuj Khandelwal Caitlin N. Kent Maurie Balch Shuxia Peng Sanket J. Mishra Junpeng Deng Victor W. Day Weiya Liu Chitra Subramanian Mark Cohen Jeffery M. Holzbeierlein Robert Matts Brian S. J. Blagg
author_sort	Anuj Khandelwal
title	Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
title_short	Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
title_full	Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
title_fullStr	Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
title_full_unstemmed	Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
title_sort	structure-guided design of an hsp90β n-terminal isoform-selective inhibitor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/22d6d57dbf0548efa5ef84106a4676a4
work_keys_str_mv	AT anujkhandelwal structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT caitlinnkent structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT mauriebalch structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT shuxiapeng structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT sanketjmishra structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT junpengdeng structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT victorwday structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT weiyaliu structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT chitrasubramanian structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT markcohen structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT jefferymholzbeierlein structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT robertmatts structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor AT briansjblagg structureguideddesignofanhsp90bnterminalisoformselectiveinhibitor
_version_	1718383264929939456

Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor

Ejemplares similares