Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States

Abstract The impact of overlapping risk factors on coronavirus disease (COVID-19) severity is unclear. To evaluate the impact of type 2 diabetes (T2D) and obesity on COVID-19 severity, we conducted a cohort study with 28,095 anonymized COVID-19 patients using data from the COVID-19 Research Database...

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Autores principales:	Wataru Ando, Takeshi Horii, Takayuki Uematsu, Hideaki Hanaki, Koichiro Atsuda, Katsuya Otori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22d8377ae5ab46188a993ca338787581
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spelling	oai:doaj.org-article:22d8377ae5ab46188a993ca3387875812021-12-02T17:19:15ZImpact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States10.1038/s41598-021-96720-x2045-2322https://doaj.org/article/22d8377ae5ab46188a993ca3387875812021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96720-xhttps://doaj.org/toc/2045-2322Abstract The impact of overlapping risk factors on coronavirus disease (COVID-19) severity is unclear. To evaluate the impact of type 2 diabetes (T2D) and obesity on COVID-19 severity, we conducted a cohort study with 28,095 anonymized COVID-19 patients using data from the COVID-19 Research Database from January 1, 2020 to November 30, 2020. The mean age was 50.8 ± 17.5 years, and 11,802 (42%) patients were male. Data on age, race, sex, T2D complications, antidiabetic medication prescription, and body mass index ≥ 30 kg/m2 (obesity) were analysed using Cox proportional hazard models, with hospitalization risk and critical care within 30 days of COVID-19 diagnosis as the main outcomes. The risk scores were 0–4 for age ≥ 65 years, male sex, T2D, and obesity. Among the participants, 11,294 (61.9%) had obesity, and 4445 (15.8%) had T2D. T2D, obesity, and male sex were significantly associated with COVID-19 hospitalization risk. Regarding hospitalization risk scores, compared with those for hospitalization risk score 0 and critical care risk score 0, hazard ratios [95% confidence intervals] were 19.034 [10.470–34.600] and 55.803 [12.761–244.015] (P < 0.001) (P < 0.001), respectively, for risk score 4. Complications from diabetes and obesity increased hospitalization and critical care risks for COVID-19 patients.Wataru AndoTakeshi HoriiTakayuki UematsuHideaki HanakiKoichiro AtsudaKatsuya OtoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wataru Ando Takeshi Horii Takayuki Uematsu Hideaki Hanaki Koichiro Atsuda Katsuya Otori Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
description	Abstract The impact of overlapping risk factors on coronavirus disease (COVID-19) severity is unclear. To evaluate the impact of type 2 diabetes (T2D) and obesity on COVID-19 severity, we conducted a cohort study with 28,095 anonymized COVID-19 patients using data from the COVID-19 Research Database from January 1, 2020 to November 30, 2020. The mean age was 50.8 ± 17.5 years, and 11,802 (42%) patients were male. Data on age, race, sex, T2D complications, antidiabetic medication prescription, and body mass index ≥ 30 kg/m2 (obesity) were analysed using Cox proportional hazard models, with hospitalization risk and critical care within 30 days of COVID-19 diagnosis as the main outcomes. The risk scores were 0–4 for age ≥ 65 years, male sex, T2D, and obesity. Among the participants, 11,294 (61.9%) had obesity, and 4445 (15.8%) had T2D. T2D, obesity, and male sex were significantly associated with COVID-19 hospitalization risk. Regarding hospitalization risk scores, compared with those for hospitalization risk score 0 and critical care risk score 0, hazard ratios [95% confidence intervals] were 19.034 [10.470–34.600] and 55.803 [12.761–244.015] (P < 0.001) (P < 0.001), respectively, for risk score 4. Complications from diabetes and obesity increased hospitalization and critical care risks for COVID-19 patients.
format	article
author	Wataru Ando Takeshi Horii Takayuki Uematsu Hideaki Hanaki Koichiro Atsuda Katsuya Otori
author_facet	Wataru Ando Takeshi Horii Takayuki Uematsu Hideaki Hanaki Koichiro Atsuda Katsuya Otori
author_sort	Wataru Ando
title	Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title_short	Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title_full	Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title_fullStr	Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title_full_unstemmed	Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title_sort	impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the united states
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/22d8377ae5ab46188a993ca338787581
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Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States

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