Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell

ABSTRACT The opportunistic pathogen Toxoplasma gondii is highly adept at manipulating host cell functions. While inside a host cell, Toxoplasma divides within a parasitophorous vacuole from which it secretes numerous effector proteins from its dense granules. Many of these so-called GRA proteins are...

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Autor principal:	Gustavo Arrizabalaga
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	GRA16 GRA24 MYR1 ROP17 Toxoplasma gondii c-MYC Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/22d992b21b9740819ea0b6533d97f199
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spelling	oai:doaj.org-article:22d992b21b9740819ea0b6533d97f1992021-11-15T15:22:27ZNeighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell10.1128/mSphere.00523-192379-5042https://doaj.org/article/22d992b21b9740819ea0b6533d97f1992019-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00523-19https://doaj.org/toc/2379-5042ABSTRACT The opportunistic pathogen Toxoplasma gondii is highly adept at manipulating host cell functions. While inside a host cell, Toxoplasma divides within a parasitophorous vacuole from which it secretes numerous effector proteins from its dense granules. Many of these so-called GRA proteins are translocated from the parsitophorous vacuole into the host cell where they directly disrupt host signaling pathways. The machinery that drives the translocation of GRA proteins across the parasitophorous vacuole membrane is being elucidated through both genetic and biochemical approaches. A new mSphere research article (M. W. Panas, A. Ferrel, A. Naor, E. Tenborg, et al., mSphere 4:e00276-19, 2019, https://doi.org/10.1128/mSphere.00276-19) describes how the kinase ROP17, which is secreted from the parasite’s rhoptries into the host cell during invasion, regulates the translocation of GRA effectors.Gustavo ArrizabalagaAmerican Society for MicrobiologyarticleGRA16GRA24MYR1ROP17Toxoplasma gondiic-MYCMicrobiologyQR1-502ENmSphere, Vol 4, Iss 4 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	GRA16 GRA24 MYR1 ROP17 Toxoplasma gondii c-MYC Microbiology QR1-502
spellingShingle	GRA16 GRA24 MYR1 ROP17 Toxoplasma gondii c-MYC Microbiology QR1-502 Gustavo Arrizabalaga Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell
description	ABSTRACT The opportunistic pathogen Toxoplasma gondii is highly adept at manipulating host cell functions. While inside a host cell, Toxoplasma divides within a parasitophorous vacuole from which it secretes numerous effector proteins from its dense granules. Many of these so-called GRA proteins are translocated from the parsitophorous vacuole into the host cell where they directly disrupt host signaling pathways. The machinery that drives the translocation of GRA proteins across the parasitophorous vacuole membrane is being elucidated through both genetic and biochemical approaches. A new mSphere research article (M. W. Panas, A. Ferrel, A. Naor, E. Tenborg, et al., mSphere 4:e00276-19, 2019, https://doi.org/10.1128/mSphere.00276-19) describes how the kinase ROP17, which is secreted from the parasite’s rhoptries into the host cell during invasion, regulates the translocation of GRA effectors.
format	article
author	Gustavo Arrizabalaga
author_facet	Gustavo Arrizabalaga
author_sort	Gustavo Arrizabalaga
title	Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell
title_short	Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell
title_full	Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell
title_fullStr	Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell
title_full_unstemmed	Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell
title_sort	neighbors working together: a <italic toggle="yes">toxoplasma</italic> rhoptry protein that facilitates dense granule protein translocation into the host cell
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/22d992b21b9740819ea0b6533d97f199
work_keys_str_mv	AT gustavoarrizabalaga neighborsworkingtogetheraitalictoggleyestoxoplasmaitalicrhoptryproteinthatfacilitatesdensegranuleproteintranslocationintothehostcell
_version_	1718427997971677184

Neighbors Working Together: a <italic toggle="yes">Toxoplasma</italic> Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell

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