Management of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle
Andreas Rank, Oliver Weigert, Helmut OstermannMedizinische Klinik III – Grosshadern, Klinikum der Ludwig Maximilians-Universitaet Munich, Munich, GermanyAbstract: Traditionally, anti-platelet autoantibodies accelerating platelet clearance from the peripheral circulation have been recog...
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Dove Medical Press
2010
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oai:doaj.org-article:22dad4fc01334c3e9df59507aa98af482021-12-02T03:45:41ZManagement of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle1177-54751177-5491https://doaj.org/article/22dad4fc01334c3e9df59507aa98af482010-05-01T00:00:00Zhttp://www.dovepress.com/management-of-chronic-immune-thrombocytopenic-purpura-targeting-insuff-a4484https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Andreas Rank, Oliver Weigert, Helmut OstermannMedizinische Klinik III – Grosshadern, Klinikum der Ludwig Maximilians-Universitaet Munich, Munich, GermanyAbstract: Traditionally, anti-platelet autoantibodies accelerating platelet clearance from the peripheral circulation have been recognized as the primary pathopysiological mechanism in chronic immune thrombocytopenia (ITP). Recently, increasing evidence supports the co-existence of insufficient megakaryopoiesis. Inadequate low thrombopoietin (TPO) levels are associated with insufficient proliferation and differentiation of megakaryocytes, decreased proplatelet formation, and subsequent platelet release. Recently two novel activators of TPO receptors have been made available: romiplostim and eltrombopag. In several phase III studies, both agents demonstrated increase of platelet counts in about 80% of chronic ITP patients within 2 to 3 weeks. These agents substantially broaden the therapeutic options for patients with chronic ITP although long-term results are still pending. This review will provide an update on the current conception of underlying mechanisms in ITP and novel, pathophysiologically based treatment options.Keywords: immune thrombocytopenia, romiplostim, eltrombopag, megakaryopoiesis Andreas RankOliver WeigertHelmut OstermannDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2010, Iss default, Pp 139-145 (2010) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
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Medicine (General) R5-920 Andreas Rank Oliver Weigert Helmut Ostermann Management of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle |
| description |
Andreas Rank, Oliver Weigert, Helmut OstermannMedizinische Klinik III – Grosshadern, Klinikum der Ludwig Maximilians-Universitaet Munich, Munich, GermanyAbstract: Traditionally, anti-platelet autoantibodies accelerating platelet clearance from the peripheral circulation have been recognized as the primary pathopysiological mechanism in chronic immune thrombocytopenia (ITP). Recently, increasing evidence supports the co-existence of insufficient megakaryopoiesis. Inadequate low thrombopoietin (TPO) levels are associated with insufficient proliferation and differentiation of megakaryocytes, decreased proplatelet formation, and subsequent platelet release. Recently two novel activators of TPO receptors have been made available: romiplostim and eltrombopag. In several phase III studies, both agents demonstrated increase of platelet counts in about 80% of chronic ITP patients within 2 to 3 weeks. These agents substantially broaden the therapeutic options for patients with chronic ITP although long-term results are still pending. This review will provide an update on the current conception of underlying mechanisms in ITP and novel, pathophysiologically based treatment options.Keywords: immune thrombocytopenia, romiplostim, eltrombopag, megakaryopoiesis |
| format |
article |
| author |
Andreas Rank Oliver Weigert Helmut Ostermann |
| author_facet |
Andreas Rank Oliver Weigert Helmut Ostermann |
| author_sort |
Andreas Rank |
| title |
Management of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle |
| title_short |
Management of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle |
| title_full |
Management of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle |
| title_fullStr |
Management of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle |
| title_full_unstemmed |
Management of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle |
| title_sort |
management of chronic immune thrombocytopenic purpura: targeting insufficient megakaryopoiesis as a novel therapeutic principle |
| publisher |
Dove Medical Press |
| publishDate |
2010 |
| url |
https://doaj.org/article/22dad4fc01334c3e9df59507aa98af48 |
| work_keys_str_mv |
AT andreasrank managementofchronicimmunethrombocytopenicpurpuratargetinginsufficientmegakaryopoiesisasanoveltherapeuticprinciple AT oliverweigert managementofchronicimmunethrombocytopenicpurpuratargetinginsufficientmegakaryopoiesisasanoveltherapeuticprinciple AT helmutostermann managementofchronicimmunethrombocytopenicpurpuratargetinginsufficientmegakaryopoiesisasanoveltherapeuticprinciple |
| _version_ |
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