Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis

Polyisoprenyl-glycosyltransferases (PI-GTs) catalyse the addition of sugar to lipid carriers, which is the first step in the production of sugar donors for glycosylation. Here Ardiccioni et al.present the structure of a bacterial PI-GT and propose a mechanistic basis for sugar transfer.

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Autores principales:	Chiara Ardiccioni, Oliver B. Clarke, David Tomasek, Habon A. Issa, Desiree C. von Alpen, Heather L. Pond, Surajit Banerjee, Kanagalaghatta R. Rajashankar, Qun Liu, Ziqiang Guan, Chijun Li, Brian Kloss, Renato Bruni, Edda Kloppmann, Burkhard Rost, M. Chiara Manzini, Lawrence Shapiro, Filippo Mancia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22db754dc74e4afeb71d8dce6eff183f
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spelling	oai:doaj.org-article:22db754dc74e4afeb71d8dce6eff183f2021-12-02T17:33:06ZStructure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis10.1038/ncomms101752041-1723https://doaj.org/article/22db754dc74e4afeb71d8dce6eff183f2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10175https://doaj.org/toc/2041-1723Polyisoprenyl-glycosyltransferases (PI-GTs) catalyse the addition of sugar to lipid carriers, which is the first step in the production of sugar donors for glycosylation. Here Ardiccioni et al.present the structure of a bacterial PI-GT and propose a mechanistic basis for sugar transfer.Chiara ArdiccioniOliver B. ClarkeDavid TomasekHabon A. IssaDesiree C. von AlpenHeather L. PondSurajit BanerjeeKanagalaghatta R. RajashankarQun LiuZiqiang GuanChijun LiBrian KlossRenato BruniEdda KloppmannBurkhard RostM. Chiara ManziniLawrence ShapiroFilippo ManciaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chiara Ardiccioni Oliver B. Clarke David Tomasek Habon A. Issa Desiree C. von Alpen Heather L. Pond Surajit Banerjee Kanagalaghatta R. Rajashankar Qun Liu Ziqiang Guan Chijun Li Brian Kloss Renato Bruni Edda Kloppmann Burkhard Rost M. Chiara Manzini Lawrence Shapiro Filippo Mancia Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis
description	Polyisoprenyl-glycosyltransferases (PI-GTs) catalyse the addition of sugar to lipid carriers, which is the first step in the production of sugar donors for glycosylation. Here Ardiccioni et al.present the structure of a bacterial PI-GT and propose a mechanistic basis for sugar transfer.
format	article
author	Chiara Ardiccioni Oliver B. Clarke David Tomasek Habon A. Issa Desiree C. von Alpen Heather L. Pond Surajit Banerjee Kanagalaghatta R. Rajashankar Qun Liu Ziqiang Guan Chijun Li Brian Kloss Renato Bruni Edda Kloppmann Burkhard Rost M. Chiara Manzini Lawrence Shapiro Filippo Mancia
author_facet	Chiara Ardiccioni Oliver B. Clarke David Tomasek Habon A. Issa Desiree C. von Alpen Heather L. Pond Surajit Banerjee Kanagalaghatta R. Rajashankar Qun Liu Ziqiang Guan Chijun Li Brian Kloss Renato Bruni Edda Kloppmann Burkhard Rost M. Chiara Manzini Lawrence Shapiro Filippo Mancia
author_sort	Chiara Ardiccioni
title	Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis
title_short	Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis
title_full	Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis
title_fullStr	Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis
title_full_unstemmed	Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis
title_sort	structure of the polyisoprenyl-phosphate glycosyltransferase gtrb and insights into the mechanism of catalysis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/22db754dc74e4afeb71d8dce6eff183f
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Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis

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