Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis

Abstract Many pharmacologic agents were investigated for the effect to prevent delirium. We aimed to comprehensively compare the effect of the pharmacological interventions to prevent postoperative delirium. A Bayesian network meta-analysis of randomized trials was performed using random effects mod...

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Autores principales:	Sun-Kyung Park, Taeyoon Lim, Hyeyeon Cho, Hyun-Kyu Yoon, Ho-Jin Lee, Ji-Hyun Lee, Seokha Yoo, Jin-Tae Kim, Won Ho Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22e1b663f2524bebb9d9fe9558bba3c8
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spelling	oai:doaj.org-article:22e1b663f2524bebb9d9fe9558bba3c82021-12-02T17:34:40ZComparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis10.1038/s41598-021-91314-z2045-2322https://doaj.org/article/22e1b663f2524bebb9d9fe9558bba3c82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91314-zhttps://doaj.org/toc/2045-2322Abstract Many pharmacologic agents were investigated for the effect to prevent delirium. We aimed to comprehensively compare the effect of the pharmacological interventions to prevent postoperative delirium. A Bayesian network meta-analysis of randomized trials was performed using random effects model. PubMed, the Cochrane Central Register of Controlled Trials, and Embase were searched on 20 January 2021. Randomized trials comparing the effect of a drug to prevent postoperative delirium with another drug or placebo in adult patients undergoing any kind of surgery were included. Primary outcome was the postoperative incidence of delirium. Eighty-six trials with 26,992 participants were included. Dexmedetomidine, haloperidol, and atypical antipsychotics significantly decreased the incidence of delirium than placebo [dexmedetomidine: odds ratio 0.51, 95% credible interval (CrI) 0.40–0.66, moderate quality of evidence (QOE); haloperidol: odds ratio 0.59, 95% CrI 0.37–0.95, moderate QOE; atypical antipsychotics: odds ratio 0.27, 95% CrI 0.14–0.51, moderate QOE]. Dexmedetomidine and atypical antipsychotics had the highest-ranking probabilities to be the best. However, significant heterogeneity regarding diagnostic time window as well as small study effects precludes firm conclusion.Sun-Kyung ParkTaeyoon LimHyeyeon ChoHyun-Kyu YoonHo-Jin LeeJi-Hyun LeeSeokha YooJin-Tae KimWon Ho KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sun-Kyung Park Taeyoon Lim Hyeyeon Cho Hyun-Kyu Yoon Ho-Jin Lee Ji-Hyun Lee Seokha Yoo Jin-Tae Kim Won Ho Kim Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis
description	Abstract Many pharmacologic agents were investigated for the effect to prevent delirium. We aimed to comprehensively compare the effect of the pharmacological interventions to prevent postoperative delirium. A Bayesian network meta-analysis of randomized trials was performed using random effects model. PubMed, the Cochrane Central Register of Controlled Trials, and Embase were searched on 20 January 2021. Randomized trials comparing the effect of a drug to prevent postoperative delirium with another drug or placebo in adult patients undergoing any kind of surgery were included. Primary outcome was the postoperative incidence of delirium. Eighty-six trials with 26,992 participants were included. Dexmedetomidine, haloperidol, and atypical antipsychotics significantly decreased the incidence of delirium than placebo [dexmedetomidine: odds ratio 0.51, 95% credible interval (CrI) 0.40–0.66, moderate quality of evidence (QOE); haloperidol: odds ratio 0.59, 95% CrI 0.37–0.95, moderate QOE; atypical antipsychotics: odds ratio 0.27, 95% CrI 0.14–0.51, moderate QOE]. Dexmedetomidine and atypical antipsychotics had the highest-ranking probabilities to be the best. However, significant heterogeneity regarding diagnostic time window as well as small study effects precludes firm conclusion.
format	article
author	Sun-Kyung Park Taeyoon Lim Hyeyeon Cho Hyun-Kyu Yoon Ho-Jin Lee Ji-Hyun Lee Seokha Yoo Jin-Tae Kim Won Ho Kim
author_facet	Sun-Kyung Park Taeyoon Lim Hyeyeon Cho Hyun-Kyu Yoon Ho-Jin Lee Ji-Hyun Lee Seokha Yoo Jin-Tae Kim Won Ho Kim
author_sort	Sun-Kyung Park
title	Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis
title_short	Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis
title_full	Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis
title_fullStr	Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis
title_full_unstemmed	Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis
title_sort	comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/22e1b663f2524bebb9d9fe9558bba3c8
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Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis

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