JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin

Epidermal homeostasis is maintained by the activity of stem cells. Here, the authors show that deficiency of the transcription factor JunB leads to altered Notch signaling in stem cells, resulting in a cell fate switch and de novo formation of aberrant sebaceous glands, altered epidermal differentia...

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Autores principales:	Karmveer Singh, Emanuela Camera, Linda Krug, Abhijit Basu, Rajeev Kumar Pandey, Saira Munir, Meinhard Wlaschek, Stefan Kochanek, Marina Schorpp-Kistner, Mauro Picardo, Peter Angel, Catherin Niemann, Pallab Maity, Karin Scharffetter-Kochanek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22e44ec426b3467fbc580f37446b2625
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spelling	oai:doaj.org-article:22e44ec426b3467fbc580f37446b26252021-12-02T17:31:45ZJunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin10.1038/s41467-018-05726-z2041-1723https://doaj.org/article/22e44ec426b3467fbc580f37446b26252018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05726-zhttps://doaj.org/toc/2041-1723Epidermal homeostasis is maintained by the activity of stem cells. Here, the authors show that deficiency of the transcription factor JunB leads to altered Notch signaling in stem cells, resulting in a cell fate switch and de novo formation of aberrant sebaceous glands, altered epidermal differentiation and impaired barrier function.Karmveer SinghEmanuela CameraLinda KrugAbhijit BasuRajeev Kumar PandeySaira MunirMeinhard WlaschekStefan KochanekMarina Schorpp-KistnerMauro PicardoPeter AngelCatherin NiemannPallab MaityKarin Scharffetter-KochanekNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karmveer Singh Emanuela Camera Linda Krug Abhijit Basu Rajeev Kumar Pandey Saira Munir Meinhard Wlaschek Stefan Kochanek Marina Schorpp-Kistner Mauro Picardo Peter Angel Catherin Niemann Pallab Maity Karin Scharffetter-Kochanek JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
description	Epidermal homeostasis is maintained by the activity of stem cells. Here, the authors show that deficiency of the transcription factor JunB leads to altered Notch signaling in stem cells, resulting in a cell fate switch and de novo formation of aberrant sebaceous glands, altered epidermal differentiation and impaired barrier function.
format	article
author	Karmveer Singh Emanuela Camera Linda Krug Abhijit Basu Rajeev Kumar Pandey Saira Munir Meinhard Wlaschek Stefan Kochanek Marina Schorpp-Kistner Mauro Picardo Peter Angel Catherin Niemann Pallab Maity Karin Scharffetter-Kochanek
author_facet	Karmveer Singh Emanuela Camera Linda Krug Abhijit Basu Rajeev Kumar Pandey Saira Munir Meinhard Wlaschek Stefan Kochanek Marina Schorpp-Kistner Mauro Picardo Peter Angel Catherin Niemann Pallab Maity Karin Scharffetter-Kochanek
author_sort	Karmveer Singh
title	JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
title_short	JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
title_full	JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
title_fullStr	JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
title_full_unstemmed	JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
title_sort	junb defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/22e44ec426b3467fbc580f37446b2625
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JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin

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