Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies

Shuai Wang,1,2 Yi He,3 Zi Chen,1 Yanzhang Li,1 Jingping Zhao,2 Luxian Lyu4 1Department of Psychology, Chengdu Medical College, Chengdu, People’s Republic of China; 2Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center on Menta...

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Autores principales:	Wang S, He Y, Chen Z, Li Y, Zhao J, Lyu L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	ZNF804A genetic variation magnetic resonance imaging brain structure meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/22e56c56d1364f83a7cfe0fe8b375bd3
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spelling	oai:doaj.org-article:22e56c56d1364f83a7cfe0fe8b375bd32021-12-02T08:37:04ZPleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies1178-2021https://doaj.org/article/22e56c56d1364f83a7cfe0fe8b375bd32019-03-01T00:00:00Zhttps://www.dovepress.com/pleiotropic-action-of-genetic-variation-in-znf804a-on-brain-structure--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Shuai Wang,1,2 Yi He,3 Zi Chen,1 Yanzhang Li,1 Jingping Zhao,2 Luxian Lyu4 1Department of Psychology, Chengdu Medical College, Chengdu, People’s Republic of China; 2Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center on Mental Health Disorders, National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, People’s Republic of China; 3Medical Group, Department of Academic Popularization, DIAO Group, Chengdu, People’s Republic of China; 4Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China Objective: The zinc finger protein 804A (ZNF804A) gene encodes the protein 804A containing the C2H2 zinc finger structure, which plays an important role in embryonic nerve development and repair. Previous studies have shown a significant association between the ZNF804A genetic variation polymorphism rs1344706 and the risk of schizophrenia and brain structure abnormalities. However, the findings are inconsistent. Materials and methods: Seventeen studies on structural magnetic resonance imaging (sMRI), with 1,031 schizophrenia patients and 3,416 healthy controls, were included in the meta-analysis. These analyses were performed using Anisotropic Effect-Size Signed Differential Mapping (AES-SDM) software and Comprehensive Meta-Analysis (CMA) software. Results: rs1344706 risk allele carriers of schizophrenia had increased gray matter in the brain regions including frontal lobe, temporal lobe, and other brain regions, but the carriers of healthy individuals had decreased gray matter and white matter integrity in the frontal lobe, central network, and other brain regions. The results of sensitivity analysis are stable, but publication bias exists in a few analyses of indexes. Conclusion: Abnormalities of brain structure have a strong relationship with ZNF804A gene rs1344706 polymorphism, but the association may be different in healthy individuals and those with mental disorders. Keywords: ZNF804A, genetic variation, magnetic resonance imaging, brain structure, meta-analysisWang SHe YChen ZLi YZhao JLyu LDove Medical PressarticleZNF804Agenetic variationmagnetic resonance imagingbrain structuremeta-analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 721-729 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ZNF804A genetic variation magnetic resonance imaging brain structure meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	ZNF804A genetic variation magnetic resonance imaging brain structure meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang S He Y Chen Z Li Y Zhao J Lyu L Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies
description	Shuai Wang,1,2 Yi He,3 Zi Chen,1 Yanzhang Li,1 Jingping Zhao,2 Luxian Lyu4 1Department of Psychology, Chengdu Medical College, Chengdu, People’s Republic of China; 2Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center on Mental Health Disorders, National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, People’s Republic of China; 3Medical Group, Department of Academic Popularization, DIAO Group, Chengdu, People’s Republic of China; 4Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China Objective: The zinc finger protein 804A (ZNF804A) gene encodes the protein 804A containing the C2H2 zinc finger structure, which plays an important role in embryonic nerve development and repair. Previous studies have shown a significant association between the ZNF804A genetic variation polymorphism rs1344706 and the risk of schizophrenia and brain structure abnormalities. However, the findings are inconsistent. Materials and methods: Seventeen studies on structural magnetic resonance imaging (sMRI), with 1,031 schizophrenia patients and 3,416 healthy controls, were included in the meta-analysis. These analyses were performed using Anisotropic Effect-Size Signed Differential Mapping (AES-SDM) software and Comprehensive Meta-Analysis (CMA) software. Results: rs1344706 risk allele carriers of schizophrenia had increased gray matter in the brain regions including frontal lobe, temporal lobe, and other brain regions, but the carriers of healthy individuals had decreased gray matter and white matter integrity in the frontal lobe, central network, and other brain regions. The results of sensitivity analysis are stable, but publication bias exists in a few analyses of indexes. Conclusion: Abnormalities of brain structure have a strong relationship with ZNF804A gene rs1344706 polymorphism, but the association may be different in healthy individuals and those with mental disorders. Keywords: ZNF804A, genetic variation, magnetic resonance imaging, brain structure, meta-analysis
format	article
author	Wang S He Y Chen Z Li Y Zhao J Lyu L
author_facet	Wang S He Y Chen Z Li Y Zhao J Lyu L
author_sort	Wang S
title	Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies
title_short	Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies
title_full	Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies
title_fullStr	Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies
title_full_unstemmed	Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies
title_sort	pleiotropic action of genetic variation in znf804a on brain structure: a meta-analysis of magnetic resonance imaging studies
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/22e56c56d1364f83a7cfe0fe8b375bd3
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Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies

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