THE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS

Abstract. Pathogenic leptospires can infect wide spectrum of hosts and they can survive in the environment long time. The outer membrane is the cellular component participated in interaction of microorganisms and environment. In present time several proteins located in the outer membrane of leptospi...

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Autor principal:	A. N. Vaganova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	leptospira antigens outer membrane lipopolysaccharide Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/22ea864660b64780b5a683f4907b7044
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spelling	oai:doaj.org-article:22ea864660b64780b5a683f4907b70442021-11-22T07:09:45ZTHE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS2220-76192313-739810.15789/2220-7619-2011-1-29-42https://doaj.org/article/22ea864660b64780b5a683f4907b70442014-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/26https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Pathogenic leptospires can infect wide spectrum of hosts and they can survive in the environment long time. The outer membrane is the cellular component participated in interaction of microorganisms and environment. In present time several proteins located in the outer membrane of leptospires which are responsible for colonization of host organism, protection from influence of immune system of host, transport of substances in to the cell and other processes have been described. The outer membrane contains proteins and lipopolysaccharide molecules which have citotoxic effect. It was shown that regulation of protein composition of membranes depends on several factors of environment such as temperature, osmolarity, presence of certain substances in environment. Lipopolysaccharide and protein molecules of outer membranes have antigenic properties. These molecules can be used in practice as the components of vaccine against leptospiroses and diagnostic tools. Current review summarize information concerning structural organization of the outer membrane of leptospires, diversities of incoming parts of molecules and regulation of their synthesis. Moreover, perspectives of practical using of the outer membrane components in diagnostics and prevention of leptospiroses are presented.A. N. VaganovaSankt-Peterburg : NIIÈM imeni Pasteraarticleleptospiraantigensouter membranelipopolysaccharideInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 1, Iss 1, Pp 29-42 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	leptospira antigens outer membrane lipopolysaccharide Infectious and parasitic diseases RC109-216
spellingShingle	leptospira antigens outer membrane lipopolysaccharide Infectious and parasitic diseases RC109-216 A. N. Vaganova THE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS
description	Abstract. Pathogenic leptospires can infect wide spectrum of hosts and they can survive in the environment long time. The outer membrane is the cellular component participated in interaction of microorganisms and environment. In present time several proteins located in the outer membrane of leptospires which are responsible for colonization of host organism, protection from influence of immune system of host, transport of substances in to the cell and other processes have been described. The outer membrane contains proteins and lipopolysaccharide molecules which have citotoxic effect. It was shown that regulation of protein composition of membranes depends on several factors of environment such as temperature, osmolarity, presence of certain substances in environment. Lipopolysaccharide and protein molecules of outer membranes have antigenic properties. These molecules can be used in practice as the components of vaccine against leptospiroses and diagnostic tools. Current review summarize information concerning structural organization of the outer membrane of leptospires, diversities of incoming parts of molecules and regulation of their synthesis. Moreover, perspectives of practical using of the outer membrane components in diagnostics and prevention of leptospiroses are presented.
format	article
author	A. N. Vaganova
author_facet	A. N. Vaganova
author_sort	A. N. Vaganova
title	THE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS
title_short	THE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS
title_full	THE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS
title_fullStr	THE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS
title_full_unstemmed	THE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS
title_sort	outer membrane of pathogenic representatives of the leptospira genius
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/22ea864660b64780b5a683f4907b7044
work_keys_str_mv	AT anvaganova theoutermembraneofpathogenicrepresentativesoftheleptospiragenius AT anvaganova outermembraneofpathogenicrepresentativesoftheleptospiragenius
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THE OUTER MEMBRANE OF PATHOGENIC REPRESENTATIVES OF THE LEPTOSPIRA GENIUS

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