IMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL

The article presents experimental data on regulatory effect of neutrophilokine helper fractions on the macrophage (Mph) functional activity in the course of antiplague immunity formation. It has revealed that these fractions content biologically active, low-molecular weight peptides. They stimulate...

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Autores principales:	G. I. Vasilieva, I. A. Ivanova, I. A. Bespalova, N. D. Omeltchenko, A. K. Kiseleva, E. P. Doroschenko, S. Yu. Tyukavkina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	regulatory peptide fractions neutrophils macrophages functional activity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/22ebf748b4234eba946522243d24d5fb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:22ebf748b4234eba946522243d24d5fb2021-11-18T08:03:38ZIMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL1563-06252313-741X10.15789/1563-0625-2010-4-5-305-310https://doaj.org/article/22ebf748b4234eba946522243d24d5fb2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/131https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe article presents experimental data on regulatory effect of neutrophilokine helper fractions on the macrophage (Mph) functional activity in the course of antiplague immunity formation. It has revealed that these fractions content biologically active, low-molecular weight peptides. They stimulate Mph killing activity by increasing phagosome-lysosome fusion, thus boosting transformation of monocytes to Mph, and causing redistribution of macrophage subpopulations in the total cellular pool. The helper effect of neutrophilokine fractions upon functional activity of MPh is more pronounced during secondary immune response.G. I. VasilievaI. A. IvanovaI. A. BespalovaN. D. OmeltchenkoA. K. KiselevaE. P. DoroschenkoS. Yu. TyukavkinaSPb RAACIarticleregulatory peptide fractionsneutrophilsmacrophagesfunctional activityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 305-310 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	regulatory peptide fractions neutrophils macrophages functional activity Immunologic diseases. Allergy RC581-607
spellingShingle	regulatory peptide fractions neutrophils macrophages functional activity Immunologic diseases. Allergy RC581-607 G. I. Vasilieva I. A. Ivanova I. A. Bespalova N. D. Omeltchenko A. K. Kiseleva E. P. Doroschenko S. Yu. Tyukavkina IMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL
description	The article presents experimental data on regulatory effect of neutrophilokine helper fractions on the macrophage (Mph) functional activity in the course of antiplague immunity formation. It has revealed that these fractions content biologically active, low-molecular weight peptides. They stimulate Mph killing activity by increasing phagosome-lysosome fusion, thus boosting transformation of monocytes to Mph, and causing redistribution of macrophage subpopulations in the total cellular pool. The helper effect of neutrophilokine fractions upon functional activity of MPh is more pronounced during secondary immune response.
format	article
author	G. I. Vasilieva I. A. Ivanova I. A. Bespalova N. D. Omeltchenko A. K. Kiseleva E. P. Doroschenko S. Yu. Tyukavkina
author_facet	G. I. Vasilieva I. A. Ivanova I. A. Bespalova N. D. Omeltchenko A. K. Kiseleva E. P. Doroschenko S. Yu. Tyukavkina
author_sort	G. I. Vasilieva
title	IMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL
title_short	IMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL
title_full	IMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL
title_fullStr	IMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL
title_full_unstemmed	IMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL
title_sort	immunobiological activity of regulatory peptide fractions synthesized by neutrophils, as tested in a macrophage model
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/22ebf748b4234eba946522243d24d5fb
work_keys_str_mv	AT givasilieva immunobiologicalactivityofregulatorypeptidefractionssynthesizedbyneutrophilsastestedinamacrophagemodel AT iaivanova immunobiologicalactivityofregulatorypeptidefractionssynthesizedbyneutrophilsastestedinamacrophagemodel AT iabespalova immunobiologicalactivityofregulatorypeptidefractionssynthesizedbyneutrophilsastestedinamacrophagemodel AT ndomeltchenko immunobiologicalactivityofregulatorypeptidefractionssynthesizedbyneutrophilsastestedinamacrophagemodel AT akkiseleva immunobiologicalactivityofregulatorypeptidefractionssynthesizedbyneutrophilsastestedinamacrophagemodel AT epdoroschenko immunobiologicalactivityofregulatorypeptidefractionssynthesizedbyneutrophilsastestedinamacrophagemodel AT syutyukavkina immunobiologicalactivityofregulatorypeptidefractionssynthesizedbyneutrophilsastestedinamacrophagemodel
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IMMUNOBIOLOGICAL ACTIVITY OF REGULATORY PEPTIDE FRACTIONS SYNTHESIZED BY NEUTROPHILS, AS TESTED IN A MACROPHAGE MODEL

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