Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat

Abstract Odor perception can both evoke emotional states and be shaped by emotional or hedonic states. The amygdala complex plays an important role in recognition of, and response to, hedonically valenced stimuli, and has strong, reciprocal connectivity with the primary olfactory (piriform) cortex....

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Autores principales:	Brett S. East, Gloria Fleming, Samantha Vervoordt, Prachi Shah, Regina M. Sullivan, Donald A. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22eccb3446b948f2a4830cb775920755
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spelling	oai:doaj.org-article:22eccb3446b948f2a4830cb7759207552021-11-08T10:49:03ZBasolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat10.1038/s41598-021-01320-42045-2322https://doaj.org/article/22eccb3446b948f2a4830cb7759207552021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01320-4https://doaj.org/toc/2045-2322Abstract Odor perception can both evoke emotional states and be shaped by emotional or hedonic states. The amygdala complex plays an important role in recognition of, and response to, hedonically valenced stimuli, and has strong, reciprocal connectivity with the primary olfactory (piriform) cortex. Here, we used differential odor-threat conditioning in rats to test the role of basolateral amygdala (BLA) input to the piriform cortex in acquisition and expression of learned olfactory threat responses. Using local field potential recordings, we demonstrated that functional connectivity (high gamma band coherence) between the BLA and posterior piriform cortex (pPCX) is enhanced after differential threat conditioning. Optogenetic suppression of activity within the BLA prevents learned threat acquisition, as do lesions of the pPCX prior to threat conditioning (without inducing anosmia), suggesting that both regions are critical for acquisition of learned odor threat responses. However, optogenetic BLA suppression during testing did not impair threat response to the CS+ , but did induce generalization to the CS−. A similar loss of stimulus control and threat generalization was induced by selective optogenetic suppression of BLA input to pPCX. These results suggest an important role for amygdala-sensory cortical connectivity in shaping responses to threatening stimuli.Brett S. EastGloria FlemingSamantha VervoordtPrachi ShahRegina M. SullivanDonald A. WilsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brett S. East Gloria Fleming Samantha Vervoordt Prachi Shah Regina M. Sullivan Donald A. Wilson Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat
description	Abstract Odor perception can both evoke emotional states and be shaped by emotional or hedonic states. The amygdala complex plays an important role in recognition of, and response to, hedonically valenced stimuli, and has strong, reciprocal connectivity with the primary olfactory (piriform) cortex. Here, we used differential odor-threat conditioning in rats to test the role of basolateral amygdala (BLA) input to the piriform cortex in acquisition and expression of learned olfactory threat responses. Using local field potential recordings, we demonstrated that functional connectivity (high gamma band coherence) between the BLA and posterior piriform cortex (pPCX) is enhanced after differential threat conditioning. Optogenetic suppression of activity within the BLA prevents learned threat acquisition, as do lesions of the pPCX prior to threat conditioning (without inducing anosmia), suggesting that both regions are critical for acquisition of learned odor threat responses. However, optogenetic BLA suppression during testing did not impair threat response to the CS+ , but did induce generalization to the CS−. A similar loss of stimulus control and threat generalization was induced by selective optogenetic suppression of BLA input to pPCX. These results suggest an important role for amygdala-sensory cortical connectivity in shaping responses to threatening stimuli.
format	article
author	Brett S. East Gloria Fleming Samantha Vervoordt Prachi Shah Regina M. Sullivan Donald A. Wilson
author_facet	Brett S. East Gloria Fleming Samantha Vervoordt Prachi Shah Regina M. Sullivan Donald A. Wilson
author_sort	Brett S. East
title	Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat
title_short	Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat
title_full	Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat
title_fullStr	Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat
title_full_unstemmed	Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat
title_sort	basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/22eccb3446b948f2a4830cb775920755
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Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat

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