The acute satellite cell response and skeletal muscle hypertrophy following resistance training.

The extent of skeletal muscle hypertrophy in response to resistance training is highly variable in humans. The main objective of this study was to explain the nature of this variability. More specifically, we focused on the myogenic stem cell population, the satellite cell (SC) as a potential mediat...

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Autores principales:	Leeann M Bellamy, Sophie Joanisse, Amanda Grubb, Cameron J Mitchell, Bryon R McKay, Stuart M Phillips, Steven Baker, Gianni Parise
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22eeda3266934b14a4e3991cc9389b07
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spelling	oai:doaj.org-article:22eeda3266934b14a4e3991cc9389b072021-11-25T05:56:42ZThe acute satellite cell response and skeletal muscle hypertrophy following resistance training.1932-620310.1371/journal.pone.0109739https://doaj.org/article/22eeda3266934b14a4e3991cc9389b072014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109739https://doaj.org/toc/1932-6203The extent of skeletal muscle hypertrophy in response to resistance training is highly variable in humans. The main objective of this study was to explain the nature of this variability. More specifically, we focused on the myogenic stem cell population, the satellite cell (SC) as a potential mediator of hypertrophy. Twenty-three males (aged 18-35 yrs) participated in 16 wk of progressive, whole body resistance training, resulting in changes of 7.9±1.6% (range of -1.9-24.7%) and 21.0±4.0% (range of -7.0 to 51.7%) in quadriceps volume and myofibre cross-sectional area (CSA), respectively. The SC response to a single bout of resistance exercise (80% 1RM), analyzed via immunofluorescent staining resulted in an expansion of type II fibre associated SC 72 h following exercise (pre: 11.3±0.9; 72 h: 14.8±1.4 SC/type II fibre; p<0.05). Training resulted in an expansion of the SC pool associated with type I (pre: 10.7±1.1; post: 12.1±1.2 SC/type I fibre; p<0.05) and type II fibres (pre: 11.3±0.9; post: 13.0±1.2 SC/type II fibre; p<0.05). Analysis of individual SC responses revealed a correlation between the relative change in type I associated SC 24 to 72 hours following an acute bout of resistance exercise and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.566, p = 0.012) and the relative change in type II associated SC following 16 weeks of resistance training and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.493, p = 0.027). Our results suggest that the SC response to resistance exercise is related to the extent of muscular hypertrophy induced by training.Leeann M BellamySophie JoanisseAmanda GrubbCameron J MitchellBryon R McKayStuart M PhillipsSteven BakerGianni ParisePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109739 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leeann M Bellamy Sophie Joanisse Amanda Grubb Cameron J Mitchell Bryon R McKay Stuart M Phillips Steven Baker Gianni Parise The acute satellite cell response and skeletal muscle hypertrophy following resistance training.
description	The extent of skeletal muscle hypertrophy in response to resistance training is highly variable in humans. The main objective of this study was to explain the nature of this variability. More specifically, we focused on the myogenic stem cell population, the satellite cell (SC) as a potential mediator of hypertrophy. Twenty-three males (aged 18-35 yrs) participated in 16 wk of progressive, whole body resistance training, resulting in changes of 7.9±1.6% (range of -1.9-24.7%) and 21.0±4.0% (range of -7.0 to 51.7%) in quadriceps volume and myofibre cross-sectional area (CSA), respectively. The SC response to a single bout of resistance exercise (80% 1RM), analyzed via immunofluorescent staining resulted in an expansion of type II fibre associated SC 72 h following exercise (pre: 11.3±0.9; 72 h: 14.8±1.4 SC/type II fibre; p<0.05). Training resulted in an expansion of the SC pool associated with type I (pre: 10.7±1.1; post: 12.1±1.2 SC/type I fibre; p<0.05) and type II fibres (pre: 11.3±0.9; post: 13.0±1.2 SC/type II fibre; p<0.05). Analysis of individual SC responses revealed a correlation between the relative change in type I associated SC 24 to 72 hours following an acute bout of resistance exercise and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.566, p = 0.012) and the relative change in type II associated SC following 16 weeks of resistance training and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.493, p = 0.027). Our results suggest that the SC response to resistance exercise is related to the extent of muscular hypertrophy induced by training.
format	article
author	Leeann M Bellamy Sophie Joanisse Amanda Grubb Cameron J Mitchell Bryon R McKay Stuart M Phillips Steven Baker Gianni Parise
author_facet	Leeann M Bellamy Sophie Joanisse Amanda Grubb Cameron J Mitchell Bryon R McKay Stuart M Phillips Steven Baker Gianni Parise
author_sort	Leeann M Bellamy
title	The acute satellite cell response and skeletal muscle hypertrophy following resistance training.
title_short	The acute satellite cell response and skeletal muscle hypertrophy following resistance training.
title_full	The acute satellite cell response and skeletal muscle hypertrophy following resistance training.
title_fullStr	The acute satellite cell response and skeletal muscle hypertrophy following resistance training.
title_full_unstemmed	The acute satellite cell response and skeletal muscle hypertrophy following resistance training.
title_sort	acute satellite cell response and skeletal muscle hypertrophy following resistance training.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/22eeda3266934b14a4e3991cc9389b07
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The acute satellite cell response and skeletal muscle hypertrophy following resistance training.

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