Harnessing the central dogma for stringent multi-level control of gene expression

Inducible gene expression systems should minimise leaky output and offer a large achievable range of expression. Here, the authors regulate transcription and translation together to suppress noise and create digital-like responses, while maintaining a large expression range in vivo and in vitro.

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Autores principales:	F. Veronica Greco, Amir Pandi, Tobias J. Erb, Claire S. Grierson, Thomas E. Gorochowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22f102bf191448c7a52806451b4bd2dc
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spelling	oai:doaj.org-article:22f102bf191448c7a52806451b4bd2dc2021-12-02T17:03:35ZHarnessing the central dogma for stringent multi-level control of gene expression10.1038/s41467-021-21995-72041-1723https://doaj.org/article/22f102bf191448c7a52806451b4bd2dc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21995-7https://doaj.org/toc/2041-1723Inducible gene expression systems should minimise leaky output and offer a large achievable range of expression. Here, the authors regulate transcription and translation together to suppress noise and create digital-like responses, while maintaining a large expression range in vivo and in vitro.F. Veronica GrecoAmir PandiTobias J. ErbClaire S. GriersonThomas E. GorochowskiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q F. Veronica Greco Amir Pandi Tobias J. Erb Claire S. Grierson Thomas E. Gorochowski Harnessing the central dogma for stringent multi-level control of gene expression
description	Inducible gene expression systems should minimise leaky output and offer a large achievable range of expression. Here, the authors regulate transcription and translation together to suppress noise and create digital-like responses, while maintaining a large expression range in vivo and in vitro.
format	article
author	F. Veronica Greco Amir Pandi Tobias J. Erb Claire S. Grierson Thomas E. Gorochowski
author_facet	F. Veronica Greco Amir Pandi Tobias J. Erb Claire S. Grierson Thomas E. Gorochowski
author_sort	F. Veronica Greco
title	Harnessing the central dogma for stringent multi-level control of gene expression
title_short	Harnessing the central dogma for stringent multi-level control of gene expression
title_full	Harnessing the central dogma for stringent multi-level control of gene expression
title_fullStr	Harnessing the central dogma for stringent multi-level control of gene expression
title_full_unstemmed	Harnessing the central dogma for stringent multi-level control of gene expression
title_sort	harnessing the central dogma for stringent multi-level control of gene expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/22f102bf191448c7a52806451b4bd2dc
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Harnessing the central dogma for stringent multi-level control of gene expression

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