Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins

Mammalian reovirus (MRV) is a double-stranded RNA (dsRNA) virus that affects the gastrointestinal and respiratory tracts. Here, the authors present the 3.3 Å cryo-EM asymmetric reconstruction of transcribing MRV that reveals the organization of the dsRNA genome, RNA interaction with the polymerase c...

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Autores principales:	Muchen Pan, Ana L. Alvarez-Cabrera, Joon S. Kang, Lihua Wang, Chunhai Fan, Z. Hong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22f352c3fd614f9fbae6f2f2d0326311
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spelling	oai:doaj.org-article:22f352c3fd614f9fbae6f2f2d03263112021-12-02T18:34:14ZAsymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins10.1038/s41467-021-24455-42041-1723https://doaj.org/article/22f352c3fd614f9fbae6f2f2d03263112021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24455-4https://doaj.org/toc/2041-1723Mammalian reovirus (MRV) is a double-stranded RNA (dsRNA) virus that affects the gastrointestinal and respiratory tracts. Here, the authors present the 3.3 Å cryo-EM asymmetric reconstruction of transcribing MRV that reveals the organization of the dsRNA genome, RNA interaction with the polymerase complex, and how the polymerase interacts extensively with its co-factor, µ2, to form a transcription enzyme complex, which engages and regulates RNA transcription.Muchen PanAna L. Alvarez-CabreraJoon S. KangLihua WangChunhai FanZ. Hong ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Muchen Pan Ana L. Alvarez-Cabrera Joon S. Kang Lihua Wang Chunhai Fan Z. Hong Zhou Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins
description	Mammalian reovirus (MRV) is a double-stranded RNA (dsRNA) virus that affects the gastrointestinal and respiratory tracts. Here, the authors present the 3.3 Å cryo-EM asymmetric reconstruction of transcribing MRV that reveals the organization of the dsRNA genome, RNA interaction with the polymerase complex, and how the polymerase interacts extensively with its co-factor, µ2, to form a transcription enzyme complex, which engages and regulates RNA transcription.
format	article
author	Muchen Pan Ana L. Alvarez-Cabrera Joon S. Kang Lihua Wang Chunhai Fan Z. Hong Zhou
author_facet	Muchen Pan Ana L. Alvarez-Cabrera Joon S. Kang Lihua Wang Chunhai Fan Z. Hong Zhou
author_sort	Muchen Pan
title	Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins
title_short	Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins
title_full	Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins
title_fullStr	Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins
title_full_unstemmed	Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins
title_sort	asymmetric reconstruction of mammalian reovirus reveals interactions among rna, transcriptional factor µ2 and capsid proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/22f352c3fd614f9fbae6f2f2d0326311
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Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins

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