Results of the study of the pathophysiological effects of dysregulation of free-radical processes: deadlock or a new impulse?

The review presents the results of the authors' work of many years and the data of foreign studies, indicating the importance of free radical processes in etiology and pathogenesis of atherosclerosis. The justification of the idea that oxidative stress in atherosclerosis develops more often dur...

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Autores principales:	V. Z. Lankin, A. K. Tikhaze
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	free radicals modified low density lipoproteins oxidative stress carbonyl stress atherosclerosis diabetes Science Q
Acceso en línea:	https://doaj.org/article/22f55c91d1434a9ea67d1f3f452f8e3f
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spelling	oai:doaj.org-article:22f55c91d1434a9ea67d1f3f452f8e3f2021-11-23T06:14:34ZResults of the study of the pathophysiological effects of dysregulation of free-radical processes: deadlock or a new impulse?2541-94202587-959610.12737/article_590823a5489433.14864804https://doaj.org/article/22f55c91d1434a9ea67d1f3f452f8e3f2016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/211https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The review presents the results of the authors' work of many years and the data of foreign studies, indicating the importance of free radical processes in etiology and pathogenesis of atherosclerosis. The justification of the idea that oxidative stress in atherosclerosis develops more often during disorders of carbohydrate metabolism, contributing to emergence of carbonyl stress in diabetes. It is hypothesized that there is a single molecular mechanism of primary pro-atherogenic injuries of vessel walls in atherosclerosis and diabetes, which enhances the formation of carbonyl-modified low-density lipoproteins, accumulating in the foam cells. The results of recent studies indicate that oxidatively modified LDL involved not only the primary injury to the vessel walls, but also provoked the development of endothelial dysfunction, so that once again raises the issue of the need for the use of antioxidants to prevent injuries in vascular walls. It can be assumed that the result of years of intensive research of free radical process mechanisms in atherosclerosis and diabetes will be the development of new drugs for the combined therapy of these diseases that can be disposed not only reactive oxygen species and organic free radicals and reactive carbonyls, which are clearly playing an important role in the development of pro-atherogenic injuries.V. Z. LankinA. K. TikhazeScientific Сentre for Family Health and Human Reproduction Problemsarticlefree radicalsmodified low density lipoproteinsoxidative stresscarbonyl stressatherosclerosisdiabetesScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 160-167 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	free radicals modified low density lipoproteins oxidative stress carbonyl stress atherosclerosis diabetes Science Q
spellingShingle	free radicals modified low density lipoproteins oxidative stress carbonyl stress atherosclerosis diabetes Science Q V. Z. Lankin A. K. Tikhaze Results of the study of the pathophysiological effects of dysregulation of free-radical processes: deadlock or a new impulse?
description	The review presents the results of the authors' work of many years and the data of foreign studies, indicating the importance of free radical processes in etiology and pathogenesis of atherosclerosis. The justification of the idea that oxidative stress in atherosclerosis develops more often during disorders of carbohydrate metabolism, contributing to emergence of carbonyl stress in diabetes. It is hypothesized that there is a single molecular mechanism of primary pro-atherogenic injuries of vessel walls in atherosclerosis and diabetes, which enhances the formation of carbonyl-modified low-density lipoproteins, accumulating in the foam cells. The results of recent studies indicate that oxidatively modified LDL involved not only the primary injury to the vessel walls, but also provoked the development of endothelial dysfunction, so that once again raises the issue of the need for the use of antioxidants to prevent injuries in vascular walls. It can be assumed that the result of years of intensive research of free radical process mechanisms in atherosclerosis and diabetes will be the development of new drugs for the combined therapy of these diseases that can be disposed not only reactive oxygen species and organic free radicals and reactive carbonyls, which are clearly playing an important role in the development of pro-atherogenic injuries.
format	article
author	V. Z. Lankin A. K. Tikhaze
author_facet	V. Z. Lankin A. K. Tikhaze
author_sort	V. Z. Lankin
title	Results of the study of the pathophysiological effects of dysregulation of free-radical processes: deadlock or a new impulse?
title_short	Results of the study of the pathophysiological effects of dysregulation of free-radical processes: deadlock or a new impulse?
title_full	Results of the study of the pathophysiological effects of dysregulation of free-radical processes: deadlock or a new impulse?
title_fullStr	Results of the study of the pathophysiological effects of dysregulation of free-radical processes: deadlock or a new impulse?
title_full_unstemmed	Results of the study of the pathophysiological effects of dysregulation of free-radical processes: deadlock or a new impulse?
title_sort	results of the study of the pathophysiological effects of dysregulation of free-radical processes: deadlock or a new impulse?
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/22f55c91d1434a9ea67d1f3f452f8e3f
work_keys_str_mv	AT vzlankin resultsofthestudyofthepathophysiologicaleffectsofdysregulationoffreeradicalprocessesdeadlockoranewimpulse AT aktikhaze resultsofthestudyofthepathophysiologicaleffectsofdysregulationoffreeradicalprocessesdeadlockoranewimpulse
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Results of the study of the pathophysiological effects of dysregulation of free-radical processes: deadlock or a new impulse?

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