Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome

Lamina propria macrophages are at the frontline of defense against intestinal pathogens. Here the authors reveal that CCR2 and NR4A1-dependent CX3CR1+ macrophages form a dense network around the vessels in the lamina propria, and implicate this anatomical structure into prevention of systemic bacter...

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Autores principales:	Masaki Honda, Bas G. J. Surewaard, Mayuki Watanabe, Catherine C. Hedrick, Woo-Yong Lee, Kirsty Brown, Kathy D. McCoy, Paul Kubes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22f602f2ddee458286f9c7576dcb809a
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spelling	oai:doaj.org-article:22f602f2ddee458286f9c7576dcb809a2021-12-02T14:42:47ZPerivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome10.1038/s41467-020-15068-42041-1723https://doaj.org/article/22f602f2ddee458286f9c7576dcb809a2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15068-4https://doaj.org/toc/2041-1723Lamina propria macrophages are at the frontline of defense against intestinal pathogens. Here the authors reveal that CCR2 and NR4A1-dependent CX3CR1+ macrophages form a dense network around the vessels in the lamina propria, and implicate this anatomical structure into prevention of systemic bacterial dissemination.Masaki HondaBas G. J. SurewaardMayuki WatanabeCatherine C. HedrickWoo-Yong LeeKirsty BrownKathy D. McCoyPaul KubesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masaki Honda Bas G. J. Surewaard Mayuki Watanabe Catherine C. Hedrick Woo-Yong Lee Kirsty Brown Kathy D. McCoy Paul Kubes Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome
description	Lamina propria macrophages are at the frontline of defense against intestinal pathogens. Here the authors reveal that CCR2 and NR4A1-dependent CX3CR1+ macrophages form a dense network around the vessels in the lamina propria, and implicate this anatomical structure into prevention of systemic bacterial dissemination.
format	article
author	Masaki Honda Bas G. J. Surewaard Mayuki Watanabe Catherine C. Hedrick Woo-Yong Lee Kirsty Brown Kathy D. McCoy Paul Kubes
author_facet	Masaki Honda Bas G. J. Surewaard Mayuki Watanabe Catherine C. Hedrick Woo-Yong Lee Kirsty Brown Kathy D. McCoy Paul Kubes
author_sort	Masaki Honda
title	Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome
title_short	Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome
title_full	Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome
title_fullStr	Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome
title_full_unstemmed	Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome
title_sort	perivascular localization of macrophages in the intestinal mucosa is regulated by nr4a1 and the microbiome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/22f602f2ddee458286f9c7576dcb809a
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Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome

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