Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome

Lamina propria macrophages are at the frontline of defense against intestinal pathogens. Here the authors reveal that CCR2 and NR4A1-dependent CX3CR1+ macrophages form a dense network around the vessels in the lamina propria, and implicate this anatomical structure into prevention of systemic bacter...

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Bibliographic Details
Main Authors: Masaki Honda, Bas G. J. Surewaard, Mayuki Watanabe, Catherine C. Hedrick, Woo-Yong Lee, Kirsty Brown, Kathy D. McCoy, Paul Kubes
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/22f602f2ddee458286f9c7576dcb809a
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