A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells.

A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells.

Ca(2+) activated Cl(-) channels (CaCC) are up-regulated in cystic fibrosis (CF) airway surface epithelia. The presence and functional properties of CaCC make it a possible therapeutic target to compensate for the deficiency of Cl(-) secretion in CF epithelia. CaCC is activated by an increase in cyto...

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Autores principales: Lihua Liang, Owen M Woodward, Zhaohui Chen, Robert Cotter, William B Guggino
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/22fd83c4eac744e897a1462c4a18b6d9
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