Resistance to bleomycin in cancer cell lines is characterized by prolonged doubling time, reduced DNA damage and evasion of G2/M arrest and apoptosis.

Resistance to bleomycin in cancer cell lines is characterized by prolonged doubling time, reduced DNA damage and evasion of G2/M arrest and apoptosis.

<h4>Background</h4>To establish, characterize and elucidate potential mechanisms of acquired bleomycin (BLM) resistance using human cancer cell lines. Seven BLM-resistant cell lines were established by exposure to escalating BLM concentrations over a period of 16-24 months. IC50 values a...

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Autores principales: Qi Wang, Kangping Cui, Osvaldo Espin-Garcia, Dangxiao Cheng, Xiaoping Qiu, Zhuo Chen, Malcolm Moore, Robert G Bristow, Wei Xu, Sandy Der, Geoffrey Liu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/22fd847c7d26465c843158e998cd5c9e
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