Crossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury

Radiation-induced lung injury (RILI) is a form of radiation damage to normal lung tissue caused by radiotherapy (RT) for thoracic cancers, which is most commonly comprised of radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). Moreover, with the widespread utilization of immunotherapi...

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Autores principales:	Zengfu Zhang, Jialin Zhou, Vivek Verma, Xu Liu, Meng Wu, Jinming Yu, Dawei Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	radiation-induced lung injury immunotherapy-related lung injury immune checkpoint inhibitor signaling pathway pyroptosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/22fe741ecd1c40a2921ed564fc169e03
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spelling	oai:doaj.org-article:22fe741ecd1c40a2921ed564fc169e032021-12-02T00:21:12ZCrossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury1664-322410.3389/fimmu.2021.774807https://doaj.org/article/22fe741ecd1c40a2921ed564fc169e032021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.774807/fullhttps://doaj.org/toc/1664-3224Radiation-induced lung injury (RILI) is a form of radiation damage to normal lung tissue caused by radiotherapy (RT) for thoracic cancers, which is most commonly comprised of radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). Moreover, with the widespread utilization of immunotherapies such as immune checkpoint inhibitors as first- and second-line treatments for various cancers, the incidence of immunotherapy-related lung injury (IRLI), a severe immune-related adverse event (irAE), has rapidly increased. To date, we know relatively little about the underlying mechanisms and signaling pathways of these complications. A better understanding of the signaling pathways may facilitate the prevention of lung injury and exploration of potential therapeutic targets. Therefore, this review provides an overview of the signaling pathways of RILI and IRLI and focuses on their crosstalk in diverse signaling pathways as well as on possible mechanisms of adverse events resulting from combined radiotherapy and immunotherapy. Furthermore, this review proposes potential therapeutic targets and avenues of further research based on signaling pathways. Many new studies on pyroptosis have renewed appreciation for the value and importance of pyroptosis in lung injury. Therefore, the authors posit that pyroptosis may be the common downstream pathway of RILI and IRLI; discussion is also conducted regarding further perspectives on pyroptosis as a crucial signaling pathway in lung injury treatment.Zengfu ZhangZengfu ZhangJialin ZhouJialin ZhouVivek VermaXu LiuMeng WuJinming YuDawei ChenDawei ChenFrontiers Media S.A.articleradiation-induced lung injuryimmunotherapy-related lung injuryimmune checkpoint inhibitorsignaling pathwaypyroptosisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiation-induced lung injury immunotherapy-related lung injury immune checkpoint inhibitor signaling pathway pyroptosis Immunologic diseases. Allergy RC581-607
spellingShingle	radiation-induced lung injury immunotherapy-related lung injury immune checkpoint inhibitor signaling pathway pyroptosis Immunologic diseases. Allergy RC581-607 Zengfu Zhang Zengfu Zhang Jialin Zhou Jialin Zhou Vivek Verma Xu Liu Meng Wu Jinming Yu Dawei Chen Dawei Chen Crossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury
description	Radiation-induced lung injury (RILI) is a form of radiation damage to normal lung tissue caused by radiotherapy (RT) for thoracic cancers, which is most commonly comprised of radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). Moreover, with the widespread utilization of immunotherapies such as immune checkpoint inhibitors as first- and second-line treatments for various cancers, the incidence of immunotherapy-related lung injury (IRLI), a severe immune-related adverse event (irAE), has rapidly increased. To date, we know relatively little about the underlying mechanisms and signaling pathways of these complications. A better understanding of the signaling pathways may facilitate the prevention of lung injury and exploration of potential therapeutic targets. Therefore, this review provides an overview of the signaling pathways of RILI and IRLI and focuses on their crosstalk in diverse signaling pathways as well as on possible mechanisms of adverse events resulting from combined radiotherapy and immunotherapy. Furthermore, this review proposes potential therapeutic targets and avenues of further research based on signaling pathways. Many new studies on pyroptosis have renewed appreciation for the value and importance of pyroptosis in lung injury. Therefore, the authors posit that pyroptosis may be the common downstream pathway of RILI and IRLI; discussion is also conducted regarding further perspectives on pyroptosis as a crucial signaling pathway in lung injury treatment.
format	article
author	Zengfu Zhang Zengfu Zhang Jialin Zhou Jialin Zhou Vivek Verma Xu Liu Meng Wu Jinming Yu Dawei Chen Dawei Chen
author_facet	Zengfu Zhang Zengfu Zhang Jialin Zhou Jialin Zhou Vivek Verma Xu Liu Meng Wu Jinming Yu Dawei Chen Dawei Chen
author_sort	Zengfu Zhang
title	Crossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury
title_short	Crossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury
title_full	Crossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury
title_fullStr	Crossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury
title_full_unstemmed	Crossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury
title_sort	crossed pathways for radiation-induced and immunotherapy-related lung injury
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/22fe741ecd1c40a2921ed564fc169e03
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Crossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury

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