Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis

Neutrophil extracellular traps (NETs) are known to promote metastasis in mouse models. Here the authors show plasma redox imbalance caused by albumin oxidation to induce inflammation-independent NETosis and lung metastasis, and albumin oxidation and reduced plasma free thiol to be associated with lu...

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Auteurs principaux:	Minoru Inoue, Ryota Nakashima, Masahiro Enomoto, Yuhki Koike, Xiao Zhao, Kenneth Yip, Shao Hui Huang, John N. Waldron, Mitsuhiko Ikura, Fei-Fei Liu, Scott V. Bratman
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/22fe89aefc79448c91736fa156901f56
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spelling	oai:doaj.org-article:22fe89aefc79448c91736fa156901f562021-12-02T17:31:59ZPlasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis10.1038/s41467-018-07550-x2041-1723https://doaj.org/article/22fe89aefc79448c91736fa156901f562018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07550-xhttps://doaj.org/toc/2041-1723Neutrophil extracellular traps (NETs) are known to promote metastasis in mouse models. Here the authors show plasma redox imbalance caused by albumin oxidation to induce inflammation-independent NETosis and lung metastasis, and albumin oxidation and reduced plasma free thiol to be associated with lung metastasis in a cohort of head and neck cancer patients.Minoru InoueRyota NakashimaMasahiro EnomotoYuhki KoikeXiao ZhaoKenneth YipShao Hui HuangJohn N. WaldronMitsuhiko IkuraFei-Fei LiuScott V. BratmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minoru Inoue Ryota Nakashima Masahiro Enomoto Yuhki Koike Xiao Zhao Kenneth Yip Shao Hui Huang John N. Waldron Mitsuhiko Ikura Fei-Fei Liu Scott V. Bratman Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis
description	Neutrophil extracellular traps (NETs) are known to promote metastasis in mouse models. Here the authors show plasma redox imbalance caused by albumin oxidation to induce inflammation-independent NETosis and lung metastasis, and albumin oxidation and reduced plasma free thiol to be associated with lung metastasis in a cohort of head and neck cancer patients.
format	article
author	Minoru Inoue Ryota Nakashima Masahiro Enomoto Yuhki Koike Xiao Zhao Kenneth Yip Shao Hui Huang John N. Waldron Mitsuhiko Ikura Fei-Fei Liu Scott V. Bratman
author_facet	Minoru Inoue Ryota Nakashima Masahiro Enomoto Yuhki Koike Xiao Zhao Kenneth Yip Shao Hui Huang John N. Waldron Mitsuhiko Ikura Fei-Fei Liu Scott V. Bratman
author_sort	Minoru Inoue
title	Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis
title_short	Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis
title_full	Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis
title_fullStr	Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis
title_full_unstemmed	Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis
title_sort	plasma redox imbalance caused by albumin oxidation promotes lung-predominant netosis and pulmonary cancer metastasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/22fe89aefc79448c91736fa156901f56
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Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis

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