Higher premature atrial complex burden from the Holter examination predicts poor cardiovascular outcome

Abstract Premature atrial complexes (PACs) have been suggested to increase the risk of adverse events. The distribution of PAC burden and its dose–response effects on all-cause mortality and cardiovascular death had not been elucidated clearly. We analyzed 15,893 patients in a medical referral cente...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ting-Chun Huang, Po-Tseng Lee, Mu-Shiang Huang, Pei-Fang Su, Ping-Yen Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2300314fcf4e4763aa10bb7ae30e9deb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2300314fcf4e4763aa10bb7ae30e9deb
record_format	dspace
spelling	oai:doaj.org-article:2300314fcf4e4763aa10bb7ae30e9deb2021-12-02T17:52:25ZHigher premature atrial complex burden from the Holter examination predicts poor cardiovascular outcome10.1038/s41598-021-91800-42045-2322https://doaj.org/article/2300314fcf4e4763aa10bb7ae30e9deb2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91800-4https://doaj.org/toc/2045-2322Abstract Premature atrial complexes (PACs) have been suggested to increase the risk of adverse events. The distribution of PAC burden and its dose–response effects on all-cause mortality and cardiovascular death had not been elucidated clearly. We analyzed 15,893 patients in a medical referral center from July 1st, 2011, to December 31st, 2018. Multivariate regression driven by ln PAC (beats per 24 h plus 1) or quartiles of PAC burden were examined. Older group had higher PAC burden than younger group (p for trend < 0.001), and both genders shared similar PACs distribution. In Cox model, ln PAC remained an independent risk factor for all-cause mortality (hazard ratio (HR) = 1.09 per ln PAC increase, 95% CI = 1.06‒1.12, p < 0.001). PACs were a significant risk factor in cause-specific model (HR = 1.13, 95% CI = 1.05‒1.22, p = 0.001) or sub-distribution model (HR = 1.12, 95% CI = 1.04‒1.21, p = 0.004). In ordinal PAC model, 4th quartile group had significantly higher risk of all-cause mortality than those in 1st quartile group (HR = 1.47, 95% CI = 1.13‒1.94, p = 0.005), but no difference in cardiovascular death were found in competing risk analysis. In subgroup analysis, the risk of high PAC burden was consistently higher than in low-burden group across pre-specified subgroups. In conclusion, PAC burden has a dose response effect on all-cause mortality and cardiovascular death.Ting-Chun HuangPo-Tseng LeeMu-Shiang HuangPei-Fang SuPing-Yen LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ting-Chun Huang Po-Tseng Lee Mu-Shiang Huang Pei-Fang Su Ping-Yen Liu Higher premature atrial complex burden from the Holter examination predicts poor cardiovascular outcome
description	Abstract Premature atrial complexes (PACs) have been suggested to increase the risk of adverse events. The distribution of PAC burden and its dose–response effects on all-cause mortality and cardiovascular death had not been elucidated clearly. We analyzed 15,893 patients in a medical referral center from July 1st, 2011, to December 31st, 2018. Multivariate regression driven by ln PAC (beats per 24 h plus 1) or quartiles of PAC burden were examined. Older group had higher PAC burden than younger group (p for trend < 0.001), and both genders shared similar PACs distribution. In Cox model, ln PAC remained an independent risk factor for all-cause mortality (hazard ratio (HR) = 1.09 per ln PAC increase, 95% CI = 1.06‒1.12, p < 0.001). PACs were a significant risk factor in cause-specific model (HR = 1.13, 95% CI = 1.05‒1.22, p = 0.001) or sub-distribution model (HR = 1.12, 95% CI = 1.04‒1.21, p = 0.004). In ordinal PAC model, 4th quartile group had significantly higher risk of all-cause mortality than those in 1st quartile group (HR = 1.47, 95% CI = 1.13‒1.94, p = 0.005), but no difference in cardiovascular death were found in competing risk analysis. In subgroup analysis, the risk of high PAC burden was consistently higher than in low-burden group across pre-specified subgroups. In conclusion, PAC burden has a dose response effect on all-cause mortality and cardiovascular death.
format	article
author	Ting-Chun Huang Po-Tseng Lee Mu-Shiang Huang Pei-Fang Su Ping-Yen Liu
author_facet	Ting-Chun Huang Po-Tseng Lee Mu-Shiang Huang Pei-Fang Su Ping-Yen Liu
author_sort	Ting-Chun Huang
title	Higher premature atrial complex burden from the Holter examination predicts poor cardiovascular outcome
title_short	Higher premature atrial complex burden from the Holter examination predicts poor cardiovascular outcome
title_full	Higher premature atrial complex burden from the Holter examination predicts poor cardiovascular outcome
title_fullStr	Higher premature atrial complex burden from the Holter examination predicts poor cardiovascular outcome
title_full_unstemmed	Higher premature atrial complex burden from the Holter examination predicts poor cardiovascular outcome
title_sort	higher premature atrial complex burden from the holter examination predicts poor cardiovascular outcome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2300314fcf4e4763aa10bb7ae30e9deb
work_keys_str_mv	AT tingchunhuang higherprematureatrialcomplexburdenfromtheholterexaminationpredictspoorcardiovascularoutcome AT potsenglee higherprematureatrialcomplexburdenfromtheholterexaminationpredictspoorcardiovascularoutcome AT mushianghuang higherprematureatrialcomplexburdenfromtheholterexaminationpredictspoorcardiovascularoutcome AT peifangsu higherprematureatrialcomplexburdenfromtheholterexaminationpredictspoorcardiovascularoutcome AT pingyenliu higherprematureatrialcomplexburdenfromtheholterexaminationpredictspoorcardiovascularoutcome
_version_	1718379214714961920

Higher premature atrial complex burden from the Holter examination predicts poor cardiovascular outcome

Ejemplares similares