Counterregulation of cAMP-directed kinase activities controls ciliogenesis

Counterregulation of cAMP-directed kinase activities controls ciliogenesis

The mechanisms that control ciliogenesis have been extensively explored however the signaling mechanisms that control cilium stability remain unclear. Here the authors show that GPCR signaling regulates cilia resorption via the ubiquitin-proteasome system.

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Detalles Bibliográficos
Autores principales: Monia Porpora, Simona Sauchella, Laura Rinaldi, Rossella Delle Donne, Maria Sepe, Omar Torres-Quesada, Daniela Intartaglia, Corrado Garbi, Luigi Insabato, Margherita Santoriello, Verena A. Bachmann, Matthis Synofzik, Herbert H. Lindner, Ivan Conte, Eduard Stefan, Antonio Feliciello
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/23040612179646c4bd606c5eb5df82fa
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Descripción
Sumario:The mechanisms that control ciliogenesis have been extensively explored however the signaling mechanisms that control cilium stability remain unclear. Here the authors show that GPCR signaling regulates cilia resorption via the ubiquitin-proteasome system.

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