Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

Risk loci for type 2 diabetes (T2D) reside in pancreatic islet enhancers. Here, the authors generate high-resolution maps of islet chromatin conformation using Hi-C which they combine with ATAC-seq and ChIP-seq data to annotate candidate target genes of enhancers and validate IGF2BP2 activity in mou...

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Main Authors: William W. Greenwald, Joshua Chiou, Jian Yan, Yunjiang Qiu, Ning Dai, Allen Wang, Naoki Nariai, Anthony Aylward, Jee Yun Han, Nikita Kadakia, Laura Regue, Mei-Lin Okino, Frauke Drees, Dana Kramer, Nicholas Vinckier, Liliana Minichiello, David Gorkin, Joseph Avruch, Kelly A. Frazer, Maike Sander, Bing Ren, Kyle J. Gaulton
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/2308d1b8b59042bb8921a23b1acf35fe
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Summary:Risk loci for type 2 diabetes (T2D) reside in pancreatic islet enhancers. Here, the authors generate high-resolution maps of islet chromatin conformation using Hi-C which they combine with ATAC-seq and ChIP-seq data to annotate candidate target genes of enhancers and validate IGF2BP2 activity in mouse islets.

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