Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

Risk loci for type 2 diabetes (T2D) reside in pancreatic islet enhancers. Here, the authors generate high-resolution maps of islet chromatin conformation using Hi-C which they combine with ATAC-seq and ChIP-seq data to annotate candidate target genes of enhancers and validate IGF2BP2 activity in mou...

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Autores principales: William W. Greenwald, Joshua Chiou, Jian Yan, Yunjiang Qiu, Ning Dai, Allen Wang, Naoki Nariai, Anthony Aylward, Jee Yun Han, Nikita Kadakia, Laura Regue, Mei-Lin Okino, Frauke Drees, Dana Kramer, Nicholas Vinckier, Liliana Minichiello, David Gorkin, Joseph Avruch, Kelly A. Frazer, Maike Sander, Bing Ren, Kyle J. Gaulton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2308d1b8b59042bb8921a23b1acf35fe
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spelling oai:doaj.org-article:2308d1b8b59042bb8921a23b1acf35fe2021-12-02T15:36:23ZPancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk10.1038/s41467-019-09975-42041-1723https://doaj.org/article/2308d1b8b59042bb8921a23b1acf35fe2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09975-4https://doaj.org/toc/2041-1723Risk loci for type 2 diabetes (T2D) reside in pancreatic islet enhancers. Here, the authors generate high-resolution maps of islet chromatin conformation using Hi-C which they combine with ATAC-seq and ChIP-seq data to annotate candidate target genes of enhancers and validate IGF2BP2 activity in mouse islets.William W. GreenwaldJoshua ChiouJian YanYunjiang QiuNing DaiAllen WangNaoki NariaiAnthony AylwardJee Yun HanNikita KadakiaLaura RegueMei-Lin OkinoFrauke DreesDana KramerNicholas VinckierLiliana MinichielloDavid GorkinJoseph AvruchKelly A. FrazerMaike SanderBing RenKyle J. GaultonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
William W. Greenwald
Joshua Chiou
Jian Yan
Yunjiang Qiu
Ning Dai
Allen Wang
Naoki Nariai
Anthony Aylward
Jee Yun Han
Nikita Kadakia
Laura Regue
Mei-Lin Okino
Frauke Drees
Dana Kramer
Nicholas Vinckier
Liliana Minichiello
David Gorkin
Joseph Avruch
Kelly A. Frazer
Maike Sander
Bing Ren
Kyle J. Gaulton
Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
description Risk loci for type 2 diabetes (T2D) reside in pancreatic islet enhancers. Here, the authors generate high-resolution maps of islet chromatin conformation using Hi-C which they combine with ATAC-seq and ChIP-seq data to annotate candidate target genes of enhancers and validate IGF2BP2 activity in mouse islets.
format article
author William W. Greenwald
Joshua Chiou
Jian Yan
Yunjiang Qiu
Ning Dai
Allen Wang
Naoki Nariai
Anthony Aylward
Jee Yun Han
Nikita Kadakia
Laura Regue
Mei-Lin Okino
Frauke Drees
Dana Kramer
Nicholas Vinckier
Liliana Minichiello
David Gorkin
Joseph Avruch
Kelly A. Frazer
Maike Sander
Bing Ren
Kyle J. Gaulton
author_facet William W. Greenwald
Joshua Chiou
Jian Yan
Yunjiang Qiu
Ning Dai
Allen Wang
Naoki Nariai
Anthony Aylward
Jee Yun Han
Nikita Kadakia
Laura Regue
Mei-Lin Okino
Frauke Drees
Dana Kramer
Nicholas Vinckier
Liliana Minichiello
David Gorkin
Joseph Avruch
Kelly A. Frazer
Maike Sander
Bing Ren
Kyle J. Gaulton
author_sort William W. Greenwald
title Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
title_short Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
title_full Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
title_fullStr Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
title_full_unstemmed Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
title_sort pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/2308d1b8b59042bb8921a23b1acf35fe
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