In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma

Primary aldosteronism is the most common form of secondary hypertension, and aldosteronoma makes up a significant proportion of primary aldosteronism cases. Aldosteronoma is also called aldosterone-producing adenoma (APA). Although there have been many studies about APA, the pathogenesis of this dis...

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Autores principales:	Yongfa Dai, Jing Li, Hong Wen, Jie Liu, Jianling Li
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi - Cambridge University Press 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/23090ecce74e4153be0f77f2351f21c4
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spelling	oai:doaj.org-article:23090ecce74e4153be0f77f2351f21c42021-12-02T19:24:16ZIn Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma0016-67231469-507310.1155/2021/9553637https://doaj.org/article/23090ecce74e4153be0f77f2351f21c42021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9553637https://doaj.org/toc/0016-6723https://doaj.org/toc/1469-5073Primary aldosteronism is the most common form of secondary hypertension, and aldosteronoma makes up a significant proportion of primary aldosteronism cases. Aldosteronoma is also called aldosterone-producing adenoma (APA). Although there have been many studies about APA, the pathogenesis of this disease is not yet fully understood. In this study, we aimed to find out the difference of gene expression patterns between APA and nonfunctional adrenocortical adenoma (NFAA) using a weighted gene coexpression network (WGCNA) and differentially expressed gene (DEG) analysis; only the genes that meet the corresponding standards of both methods were defined as real hub genes and then used for further analysis. Twenty-nine real hub genes were found out, most of which were enriched in the phospholipid metabolic process. WISP2, S100A10, SSTR5-AS1, SLC29A1, APOC1, and SLITRK4 are six real hub genes with the same gene expression pattern between the combined and validation datasets, three of which indirectly or directly participate in lipid metabolism including WISP2, S100A10, and APOC1. According to the gene expression pattern of DEGs, we speculated five candidate drugs with potential therapeutic value for APA, one of which is cycloheximide, an inhibitor for phospholipid biosynthesis. All the evidence suggests that phospholipid metabolism may be an important pathophysiological mechanism for APA. Our study provides a new perspective regarding the pathophysiological mechanism of APA and offers some small molecules that may possibly be effective drugs against APA.Yongfa DaiJing LiHong WenJie LiuJianling LiHindawi - Cambridge University PressarticleGeneticsQH426-470ENGenetics Research, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Yongfa Dai Jing Li Hong Wen Jie Liu Jianling Li In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma
description	Primary aldosteronism is the most common form of secondary hypertension, and aldosteronoma makes up a significant proportion of primary aldosteronism cases. Aldosteronoma is also called aldosterone-producing adenoma (APA). Although there have been many studies about APA, the pathogenesis of this disease is not yet fully understood. In this study, we aimed to find out the difference of gene expression patterns between APA and nonfunctional adrenocortical adenoma (NFAA) using a weighted gene coexpression network (WGCNA) and differentially expressed gene (DEG) analysis; only the genes that meet the corresponding standards of both methods were defined as real hub genes and then used for further analysis. Twenty-nine real hub genes were found out, most of which were enriched in the phospholipid metabolic process. WISP2, S100A10, SSTR5-AS1, SLC29A1, APOC1, and SLITRK4 are six real hub genes with the same gene expression pattern between the combined and validation datasets, three of which indirectly or directly participate in lipid metabolism including WISP2, S100A10, and APOC1. According to the gene expression pattern of DEGs, we speculated five candidate drugs with potential therapeutic value for APA, one of which is cycloheximide, an inhibitor for phospholipid biosynthesis. All the evidence suggests that phospholipid metabolism may be an important pathophysiological mechanism for APA. Our study provides a new perspective regarding the pathophysiological mechanism of APA and offers some small molecules that may possibly be effective drugs against APA.
format	article
author	Yongfa Dai Jing Li Hong Wen Jie Liu Jianling Li
author_facet	Yongfa Dai Jing Li Hong Wen Jie Liu Jianling Li
author_sort	Yongfa Dai
title	In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma
title_short	In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma
title_full	In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma
title_fullStr	In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma
title_full_unstemmed	In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma
title_sort	in silico analysis of the gene expression patterns between aldosterone-producing adenoma and nonfunctional adrenocortical adenoma
publisher	Hindawi - Cambridge University Press
publishDate	2021
url	https://doaj.org/article/23090ecce74e4153be0f77f2351f21c4
work_keys_str_mv	AT yongfadai insilicoanalysisofthegeneexpressionpatternsbetweenaldosteroneproducingadenomaandnonfunctionaladrenocorticaladenoma AT jingli insilicoanalysisofthegeneexpressionpatternsbetweenaldosteroneproducingadenomaandnonfunctionaladrenocorticaladenoma AT hongwen insilicoanalysisofthegeneexpressionpatternsbetweenaldosteroneproducingadenomaandnonfunctionaladrenocorticaladenoma AT jieliu insilicoanalysisofthegeneexpressionpatternsbetweenaldosteroneproducingadenomaandnonfunctionaladrenocorticaladenoma AT jianlingli insilicoanalysisofthegeneexpressionpatternsbetweenaldosteroneproducingadenomaandnonfunctionaladrenocorticaladenoma
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In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma

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