Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanoma.

Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanoma.

Nucleotide excision repair (NER) orchestrates the repair of helix distorting DNA damage, induced by both ultraviolet radiation (UVR) and cisplatin. There is evidence that the global genome repair (GGR) arm of NER is dysfunctional in melanoma and it is known to have limited induction in melanoma cell...

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Autores principales: Nikola A Bowden, Katie A Ashton, Ricardo E Vilain, Kelly A Avery-Kiejda, Ryan J Davey, Heather C Murray, Timothy Budden, Stephen G Braye, Xu Dong Zhang, Peter Hersey, Rodney J Scott
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/230d2908070146acaf291933e25de21c
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