Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods

Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. To mitigate the side effects of URAT1-targeted clinical agents such as benzbromarone, there is significant interes...

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Autores principales:	Ying Chen, Ruya You, Ke Wang, Yousheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/230e01384c354a898aa66ccf47cbe072
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spelling	oai:doaj.org-article:230e01384c354a898aa66ccf47cbe0722021-11-08T02:35:28ZRecent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods1741-428810.1155/2021/5738900https://doaj.org/article/230e01384c354a898aa66ccf47cbe0722021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5738900https://doaj.org/toc/1741-4288Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. To mitigate the side effects of URAT1-targeted clinical agents such as benzbromarone, there is significant interest in discovering new URAT1 inhibitors and developing technology that can evaluate URAT1 inhibition. This review summarizes the methods for assay of URAT1 inhibition and the progress on the discovery of natural and synthetic URAT1 inhibitors in the past five years.Ying ChenRuya YouKe WangYousheng WangHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Ying Chen Ruya You Ke Wang Yousheng Wang Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
description	Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. To mitigate the side effects of URAT1-targeted clinical agents such as benzbromarone, there is significant interest in discovering new URAT1 inhibitors and developing technology that can evaluate URAT1 inhibition. This review summarizes the methods for assay of URAT1 inhibition and the progress on the discovery of natural and synthetic URAT1 inhibitors in the past five years.
format	article
author	Ying Chen Ruya You Ke Wang Yousheng Wang
author_facet	Ying Chen Ruya You Ke Wang Yousheng Wang
author_sort	Ying Chen
title	Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title_short	Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title_full	Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title_fullStr	Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title_full_unstemmed	Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title_sort	recent updates of natural and synthetic urat1 inhibitors and novel screening methods
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/230e01384c354a898aa66ccf47cbe072
work_keys_str_mv	AT yingchen recentupdatesofnaturalandsyntheticurat1inhibitorsandnovelscreeningmethods AT ruyayou recentupdatesofnaturalandsyntheticurat1inhibitorsandnovelscreeningmethods AT kewang recentupdatesofnaturalandsyntheticurat1inhibitorsandnovelscreeningmethods AT youshengwang recentupdatesofnaturalandsyntheticurat1inhibitorsandnovelscreeningmethods
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Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods

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