Pharmacothera-peutic activity Lomatogonium Carinthiacum extract at experimental hepatitis

Pharmacotherapeutic efficiency of the dry extract from Lomatogonium carinthiacum in toxic hepatitis was studied. Experimental hepatitis was caused by the introduction of tetracycline hydrochloride to Wistar white rats in the dose of 1,0 g/kg of the animal weight once a day during 7 days. The extract...

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Autores principales:	A. V. Fedorov, S. M. Nikolaev, Z. G. Sambuyeva, Ya. G. Razuvaeva, A. A. Toropova, E. V. Ferubko
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	lomatogonium carinthiacum (wulf.) reichenb extract hepatoprotective effect Science Q
Acceso en línea:	https://doaj.org/article/230ebc9d25ac4873968b94b7765388b0
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spelling	oai:doaj.org-article:230ebc9d25ac4873968b94b7765388b02021-11-23T06:14:29ZPharmacothera-peutic activity Lomatogonium Carinthiacum extract at experimental hepatitis2541-94202587-9596https://doaj.org/article/230ebc9d25ac4873968b94b7765388b02013-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1665https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Pharmacotherapeutic efficiency of the dry extract from Lomatogonium carinthiacum in toxic hepatitis was studied. Experimental hepatitis was caused by the introduction of tetracycline hydrochloride to Wistar white rats in the dose of 1,0 g/kg of the animal weight once a day during 7 days. The extract from L. carinthiacum was administered per os in the dose of 100 mg/kg during 26 days. It was established that the extract from L. carinthiacum had a marked hepatoprotective effect in the case of tetracycline hepatitis in white rats that is characterized by inhibition of the disturbances in choleretic and cholate-synthetic functions of the liver: the increase of bile secretion rate, preservation of cholate concentration in the bile, the decrease in the content of cholesterol triacylglycerides and alkaline phosphatase activity in the animal blood serum during the whole period of experiments. The tested remedy diminishes dystrophic and necrotic processes in hepatocytes, decreases the intensity of inflammatory infiltration in the liver and stimulates regeneration of liver cells in tetracycline hepatitis. The decrease of MDA content in the liver homogenate and increase in catalase activity against the same indices in control animals testify the marked antioxidant effect of L. carinthiacum.A. V. FedorovS. M. NikolaevZ. G. SambuyevaYa. G. RazuvaevaA. A. ToropovaE. V. FerubkoScientific Сentre for Family Health and Human Reproduction Problemsarticlelomatogonium carinthiacum (wulf.) reichenblomatogonium carinthiacum (wulf.) reichenbextracthepatoprotective effectScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5, Pp 162-166 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	lomatogonium carinthiacum (wulf.) reichenb lomatogonium carinthiacum (wulf.) reichenb extract hepatoprotective effect Science Q
spellingShingle	lomatogonium carinthiacum (wulf.) reichenb lomatogonium carinthiacum (wulf.) reichenb extract hepatoprotective effect Science Q A. V. Fedorov S. M. Nikolaev Z. G. Sambuyeva Ya. G. Razuvaeva A. A. Toropova E. V. Ferubko Pharmacothera-peutic activity Lomatogonium Carinthiacum extract at experimental hepatitis
description	Pharmacotherapeutic efficiency of the dry extract from Lomatogonium carinthiacum in toxic hepatitis was studied. Experimental hepatitis was caused by the introduction of tetracycline hydrochloride to Wistar white rats in the dose of 1,0 g/kg of the animal weight once a day during 7 days. The extract from L. carinthiacum was administered per os in the dose of 100 mg/kg during 26 days. It was established that the extract from L. carinthiacum had a marked hepatoprotective effect in the case of tetracycline hepatitis in white rats that is characterized by inhibition of the disturbances in choleretic and cholate-synthetic functions of the liver: the increase of bile secretion rate, preservation of cholate concentration in the bile, the decrease in the content of cholesterol triacylglycerides and alkaline phosphatase activity in the animal blood serum during the whole period of experiments. The tested remedy diminishes dystrophic and necrotic processes in hepatocytes, decreases the intensity of inflammatory infiltration in the liver and stimulates regeneration of liver cells in tetracycline hepatitis. The decrease of MDA content in the liver homogenate and increase in catalase activity against the same indices in control animals testify the marked antioxidant effect of L. carinthiacum.
format	article
author	A. V. Fedorov S. M. Nikolaev Z. G. Sambuyeva Ya. G. Razuvaeva A. A. Toropova E. V. Ferubko
author_facet	A. V. Fedorov S. M. Nikolaev Z. G. Sambuyeva Ya. G. Razuvaeva A. A. Toropova E. V. Ferubko
author_sort	A. V. Fedorov
title	Pharmacothera-peutic activity Lomatogonium Carinthiacum extract at experimental hepatitis
title_short	Pharmacothera-peutic activity Lomatogonium Carinthiacum extract at experimental hepatitis
title_full	Pharmacothera-peutic activity Lomatogonium Carinthiacum extract at experimental hepatitis
title_fullStr	Pharmacothera-peutic activity Lomatogonium Carinthiacum extract at experimental hepatitis
title_full_unstemmed	Pharmacothera-peutic activity Lomatogonium Carinthiacum extract at experimental hepatitis
title_sort	pharmacothera-peutic activity lomatogonium carinthiacum extract at experimental hepatitis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/230ebc9d25ac4873968b94b7765388b0
work_keys_str_mv	AT avfedorov pharmacotherapeuticactivitylomatogoniumcarinthiacumextractatexperimentalhepatitis AT smnikolaev pharmacotherapeuticactivitylomatogoniumcarinthiacumextractatexperimentalhepatitis AT zgsambuyeva pharmacotherapeuticactivitylomatogoniumcarinthiacumextractatexperimentalhepatitis AT yagrazuvaeva pharmacotherapeuticactivitylomatogoniumcarinthiacumextractatexperimentalhepatitis AT aatoropova pharmacotherapeuticactivitylomatogoniumcarinthiacumextractatexperimentalhepatitis AT evferubko pharmacotherapeuticactivitylomatogoniumcarinthiacumextractatexperimentalhepatitis
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Pharmacothera-peutic activity Lomatogonium Carinthiacum extract at experimental hepatitis

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