Ancient DNA analysis of mid-holocene individuals from the Northwest Coast of North America reveals different evolutionary paths for mitogenomes.

To gain a better understanding of North American population history, complete mitochondrial genomes (mitogenomes) were generated from four ancient and three living individuals of the northern Northwest Coast of North America, specifically the north coast of British Columbia, Canada, current home to...

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Autores principales:	Yinqiu Cui, John Lindo, Cris E Hughes, Jesse W Johnson, Alvaro G Hernandez, Brian M Kemp, Jian Ma, Ryan Cunningham, Barbara Petzelt, Joycellyn Mitchell, David Archer, Jerome S Cybulski, Ripan S Malhi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/230fa1f070a5410d9df56d95e2efb4bc
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spelling	oai:doaj.org-article:230fa1f070a5410d9df56d95e2efb4bc2021-11-18T07:38:52ZAncient DNA analysis of mid-holocene individuals from the Northwest Coast of North America reveals different evolutionary paths for mitogenomes.1932-620310.1371/journal.pone.0066948https://doaj.org/article/230fa1f070a5410d9df56d95e2efb4bc2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23843972/?tool=EBIhttps://doaj.org/toc/1932-6203To gain a better understanding of North American population history, complete mitochondrial genomes (mitogenomes) were generated from four ancient and three living individuals of the northern Northwest Coast of North America, specifically the north coast of British Columbia, Canada, current home to the indigenous Tsimshian, Haida, and Nisga'a. The mitogenomes of all individuals were previously unknown and assigned to new sub-haplogroup designations D4h3a7, A2ag and A2ah. The analysis of mitogenomes allows for more detailed analyses of presumed ancestor-descendant relationships than sequencing only the HVSI region of the mitochondrial genome, a more traditional approach in local population studies. The results of this study provide contrasting examples of the evolution of Native American mitogenomes. Those belonging to sub-haplogroups A2ag and A2ah exhibit temporal continuity in this region for 5000 years up until the present day. Of possible associative significance is that archaeologically identified house structures in this region maintain similar characteristics for this same period of time, demonstrating cultural continuity in residence patterns. The individual dated to 6000 years before present (BP) exhibited a mitogenome belonging to sub-haplogroup D4h3a. This sub-haplogroup was earlier identified in the same general area at 10300 years BP on Prince of Wales Island, Alaska, and may have gone extinct, as it has not been observed in any living individuals of the Northwest Coast. The presented case studies demonstrate the different evolutionary paths of mitogenomes over time on the Northwest Coast.Yinqiu CuiJohn LindoCris E HughesJesse W JohnsonAlvaro G HernandezBrian M KempJian MaRyan CunninghamBarbara PetzeltJoycellyn MitchellDavid ArcherJerome S CybulskiRipan S MalhiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e66948 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yinqiu Cui John Lindo Cris E Hughes Jesse W Johnson Alvaro G Hernandez Brian M Kemp Jian Ma Ryan Cunningham Barbara Petzelt Joycellyn Mitchell David Archer Jerome S Cybulski Ripan S Malhi Ancient DNA analysis of mid-holocene individuals from the Northwest Coast of North America reveals different evolutionary paths for mitogenomes.
description	To gain a better understanding of North American population history, complete mitochondrial genomes (mitogenomes) were generated from four ancient and three living individuals of the northern Northwest Coast of North America, specifically the north coast of British Columbia, Canada, current home to the indigenous Tsimshian, Haida, and Nisga'a. The mitogenomes of all individuals were previously unknown and assigned to new sub-haplogroup designations D4h3a7, A2ag and A2ah. The analysis of mitogenomes allows for more detailed analyses of presumed ancestor-descendant relationships than sequencing only the HVSI region of the mitochondrial genome, a more traditional approach in local population studies. The results of this study provide contrasting examples of the evolution of Native American mitogenomes. Those belonging to sub-haplogroups A2ag and A2ah exhibit temporal continuity in this region for 5000 years up until the present day. Of possible associative significance is that archaeologically identified house structures in this region maintain similar characteristics for this same period of time, demonstrating cultural continuity in residence patterns. The individual dated to 6000 years before present (BP) exhibited a mitogenome belonging to sub-haplogroup D4h3a. This sub-haplogroup was earlier identified in the same general area at 10300 years BP on Prince of Wales Island, Alaska, and may have gone extinct, as it has not been observed in any living individuals of the Northwest Coast. The presented case studies demonstrate the different evolutionary paths of mitogenomes over time on the Northwest Coast.
format	article
author	Yinqiu Cui John Lindo Cris E Hughes Jesse W Johnson Alvaro G Hernandez Brian M Kemp Jian Ma Ryan Cunningham Barbara Petzelt Joycellyn Mitchell David Archer Jerome S Cybulski Ripan S Malhi
author_facet	Yinqiu Cui John Lindo Cris E Hughes Jesse W Johnson Alvaro G Hernandez Brian M Kemp Jian Ma Ryan Cunningham Barbara Petzelt Joycellyn Mitchell David Archer Jerome S Cybulski Ripan S Malhi
author_sort	Yinqiu Cui
title	Ancient DNA analysis of mid-holocene individuals from the Northwest Coast of North America reveals different evolutionary paths for mitogenomes.
title_short	Ancient DNA analysis of mid-holocene individuals from the Northwest Coast of North America reveals different evolutionary paths for mitogenomes.
title_full	Ancient DNA analysis of mid-holocene individuals from the Northwest Coast of North America reveals different evolutionary paths for mitogenomes.
title_fullStr	Ancient DNA analysis of mid-holocene individuals from the Northwest Coast of North America reveals different evolutionary paths for mitogenomes.
title_full_unstemmed	Ancient DNA analysis of mid-holocene individuals from the Northwest Coast of North America reveals different evolutionary paths for mitogenomes.
title_sort	ancient dna analysis of mid-holocene individuals from the northwest coast of north america reveals different evolutionary paths for mitogenomes.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/230fa1f070a5410d9df56d95e2efb4bc
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Ancient DNA analysis of mid-holocene individuals from the Northwest Coast of North America reveals different evolutionary paths for mitogenomes.

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