T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology

Since its emergence in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading remarkably fast worldwide. Effective countermeasures require the rapid development of data and tools to monitor its spread and better understand immunogenic profile. However, limited inf...

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Autores principales:	Hassan Md. Mehedi, Sharmin Shirina, Hong Jinny, Lee Hoi-Seon, Kim Hyeon-Jin, Hong Seong-Tshool
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	sars-cov-2 spike glycoprotein prototype proteome phylogenetic analysis malaria Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2310c8317d664306a48a1b33dc2525a9
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spelling	oai:doaj.org-article:2310c8317d664306a48a1b33dc2525a92021-12-05T14:10:41ZT cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology2391-541210.1515/biol-2021-0062https://doaj.org/article/2310c8317d664306a48a1b33dc2525a92021-06-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0062https://doaj.org/toc/2391-5412Since its emergence in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading remarkably fast worldwide. Effective countermeasures require the rapid development of data and tools to monitor its spread and better understand immunogenic profile. However, limited information is available about the tools and target of the immune responses to SARS-CoV-2. In this study, we excogitated a new approach for analyzing phylogenetic relationships by using the whole prototype proteome sequences. Phylogenetic analysis on the whole prototype proteome sequences showed that SARS-CoV-2 was a direct descendant of Bat-CoV and was closely related to Pangolin-CoV, Bat-SL-CoV, and SARS-CoV. The pairwise comparison of SARS-CoV-2 with Bat-CoV showed an unusual replacement of the motif consisting of seven amino acids (NNLDSKV) within the spike protein of SARS-CoV-2. The replaced motif in the spike protein of SARS-CoV-2 was found in 12 other species, including a conserved surface protein of a malaria-causing pathogen, Plasmodium malariae. We further identified the T and B cell epitope sequence homology of SARS-CoV-2 spike protein with conserved surface protein of P. malariae using the Immune Epitope Database and Analysis Resource (IEDB). The shared immunodominant epitopes may provide immunity against SARS-CoV-2 infection to those previously infected with P. malariae.Hassan Md. MehediSharmin ShirinaHong JinnyLee Hoi-SeonKim Hyeon-JinHong Seong-TshoolDe Gruyterarticlesars-cov-2spike glycoproteinprototypeproteomephylogenetic analysismalariaBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 630-640 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sars-cov-2 spike glycoprotein prototype proteome phylogenetic analysis malaria Biology (General) QH301-705.5
spellingShingle	sars-cov-2 spike glycoprotein prototype proteome phylogenetic analysis malaria Biology (General) QH301-705.5 Hassan Md. Mehedi Sharmin Shirina Hong Jinny Lee Hoi-Seon Kim Hyeon-Jin Hong Seong-Tshool T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology
description	Since its emergence in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading remarkably fast worldwide. Effective countermeasures require the rapid development of data and tools to monitor its spread and better understand immunogenic profile. However, limited information is available about the tools and target of the immune responses to SARS-CoV-2. In this study, we excogitated a new approach for analyzing phylogenetic relationships by using the whole prototype proteome sequences. Phylogenetic analysis on the whole prototype proteome sequences showed that SARS-CoV-2 was a direct descendant of Bat-CoV and was closely related to Pangolin-CoV, Bat-SL-CoV, and SARS-CoV. The pairwise comparison of SARS-CoV-2 with Bat-CoV showed an unusual replacement of the motif consisting of seven amino acids (NNLDSKV) within the spike protein of SARS-CoV-2. The replaced motif in the spike protein of SARS-CoV-2 was found in 12 other species, including a conserved surface protein of a malaria-causing pathogen, Plasmodium malariae. We further identified the T and B cell epitope sequence homology of SARS-CoV-2 spike protein with conserved surface protein of P. malariae using the Immune Epitope Database and Analysis Resource (IEDB). The shared immunodominant epitopes may provide immunity against SARS-CoV-2 infection to those previously infected with P. malariae.
format	article
author	Hassan Md. Mehedi Sharmin Shirina Hong Jinny Lee Hoi-Seon Kim Hyeon-Jin Hong Seong-Tshool
author_facet	Hassan Md. Mehedi Sharmin Shirina Hong Jinny Lee Hoi-Seon Kim Hyeon-Jin Hong Seong-Tshool
author_sort	Hassan Md. Mehedi
title	T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology
title_short	T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology
title_full	T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology
title_fullStr	T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology
title_full_unstemmed	T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology
title_sort	t cell epitopes of sars-cov-2 spike protein and conserved surface protein of plasmodium malariae share sequence homology
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/2310c8317d664306a48a1b33dc2525a9
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T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology

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