Understanding the genetic determinants of the brain with MOSTest

Regional brain morphology has a complex genetic architecture. Here the authors present MOSTest, a multivariate statistical framework, apply it to UK Biobank data, and discover hundreds of loci associated with regional brain morphology.

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Autores principales:	Dennis van der Meer, Oleksandr Frei, Tobias Kaufmann, Alexey A. Shadrin, Anna Devor, Olav B. Smeland, Wesley K. Thompson, Chun Chieh Fan, Dominic Holland, Lars T. Westlye, Ole A. Andreassen, Anders M. Dale
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23142a35894143158339487e31feb0c1
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spelling	oai:doaj.org-article:23142a35894143158339487e31feb0c12021-12-02T18:36:59ZUnderstanding the genetic determinants of the brain with MOSTest10.1038/s41467-020-17368-12041-1723https://doaj.org/article/23142a35894143158339487e31feb0c12020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17368-1https://doaj.org/toc/2041-1723Regional brain morphology has a complex genetic architecture. Here the authors present MOSTest, a multivariate statistical framework, apply it to UK Biobank data, and discover hundreds of loci associated with regional brain morphology.Dennis van der MeerOleksandr FreiTobias KaufmannAlexey A. ShadrinAnna DevorOlav B. SmelandWesley K. ThompsonChun Chieh FanDominic HollandLars T. WestlyeOle A. AndreassenAnders M. DaleNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dennis van der Meer Oleksandr Frei Tobias Kaufmann Alexey A. Shadrin Anna Devor Olav B. Smeland Wesley K. Thompson Chun Chieh Fan Dominic Holland Lars T. Westlye Ole A. Andreassen Anders M. Dale Understanding the genetic determinants of the brain with MOSTest
description	Regional brain morphology has a complex genetic architecture. Here the authors present MOSTest, a multivariate statistical framework, apply it to UK Biobank data, and discover hundreds of loci associated with regional brain morphology.
format	article
author	Dennis van der Meer Oleksandr Frei Tobias Kaufmann Alexey A. Shadrin Anna Devor Olav B. Smeland Wesley K. Thompson Chun Chieh Fan Dominic Holland Lars T. Westlye Ole A. Andreassen Anders M. Dale
author_facet	Dennis van der Meer Oleksandr Frei Tobias Kaufmann Alexey A. Shadrin Anna Devor Olav B. Smeland Wesley K. Thompson Chun Chieh Fan Dominic Holland Lars T. Westlye Ole A. Andreassen Anders M. Dale
author_sort	Dennis van der Meer
title	Understanding the genetic determinants of the brain with MOSTest
title_short	Understanding the genetic determinants of the brain with MOSTest
title_full	Understanding the genetic determinants of the brain with MOSTest
title_fullStr	Understanding the genetic determinants of the brain with MOSTest
title_full_unstemmed	Understanding the genetic determinants of the brain with MOSTest
title_sort	understanding the genetic determinants of the brain with mostest
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/23142a35894143158339487e31feb0c1
work_keys_str_mv	AT dennisvandermeer understandingthegeneticdeterminantsofthebrainwithmostest AT oleksandrfrei understandingthegeneticdeterminantsofthebrainwithmostest AT tobiaskaufmann understandingthegeneticdeterminantsofthebrainwithmostest AT alexeyashadrin understandingthegeneticdeterminantsofthebrainwithmostest AT annadevor understandingthegeneticdeterminantsofthebrainwithmostest AT olavbsmeland understandingthegeneticdeterminantsofthebrainwithmostest AT wesleykthompson understandingthegeneticdeterminantsofthebrainwithmostest AT chunchiehfan understandingthegeneticdeterminantsofthebrainwithmostest AT dominicholland understandingthegeneticdeterminantsofthebrainwithmostest AT larstwestlye understandingthegeneticdeterminantsofthebrainwithmostest AT oleaandreassen understandingthegeneticdeterminantsofthebrainwithmostest AT andersmdale understandingthegeneticdeterminantsofthebrainwithmostest
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Understanding the genetic determinants of the brain with MOSTest

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