Different antiviral effects of IFNα subtypes in a mouse model of HBV infection

Abstract Interferon alpha (IFNα) is commonly used for the treatment of chronic hepatitis B (CHB) patients. There are 13 different IFNα subtypes in humans, but only the subtype IFNα2 is used for clinical treatment. The antiviral activities of all other IFNα subtypes against HBV have not been studied....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jingjiao Song, Sheng Li, Yun Zhou, Jia Liu, Sandra Francois, Mengji Lu, Dongliang Yang, Ulf Dittmer, Kathrin Sutter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23174242175f492487c0baadadc7baf5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:23174242175f492487c0baadadc7baf5
record_format	dspace
spelling	oai:doaj.org-article:23174242175f492487c0baadadc7baf52021-12-02T12:30:19ZDifferent antiviral effects of IFNα subtypes in a mouse model of HBV infection10.1038/s41598-017-00469-12045-2322https://doaj.org/article/23174242175f492487c0baadadc7baf52017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00469-1https://doaj.org/toc/2045-2322Abstract Interferon alpha (IFNα) is commonly used for the treatment of chronic hepatitis B (CHB) patients. There are 13 different IFNα subtypes in humans, but only the subtype IFNα2 is used for clinical treatment. The antiviral activities of all other IFNα subtypes against HBV have not been studied. To obtain basic knowledge about the direct antiviral as well as the immunomodulatory effects of IFNα subtypes, we used the HBV hydrodynamic injection (HI) mouse model. Application of most IFNα subtype proteins inhibited HBV replication in vivo, with IFNα4 and IFNα5 being the most effective subtypes. Decreased viral loads after therapeutic application of IFNα4 and IFNα5 correlated with expanded effector cell populations of NK cells and T cells in both liver and spleen. Hydrodynamic injection of plasmids encoding for the effective IFNα subtypes (pIFNα) was even more potent against HBV than injecting IFNα proteins. The combination of pIFNα4 and pIFNα5 showed a synergistic antiviral effect on HBV replication, with a strong increase in NK cell and T cell activity. The results demonstrate distinct anti-HBV effects of different IFNα subtypes against HBV in the mouse model, which may be relevant for new therapeutic approaches.Jingjiao SongSheng LiYun ZhouJia LiuSandra FrancoisMengji LuDongliang YangUlf DittmerKathrin SutterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jingjiao Song Sheng Li Yun Zhou Jia Liu Sandra Francois Mengji Lu Dongliang Yang Ulf Dittmer Kathrin Sutter Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
description	Abstract Interferon alpha (IFNα) is commonly used for the treatment of chronic hepatitis B (CHB) patients. There are 13 different IFNα subtypes in humans, but only the subtype IFNα2 is used for clinical treatment. The antiviral activities of all other IFNα subtypes against HBV have not been studied. To obtain basic knowledge about the direct antiviral as well as the immunomodulatory effects of IFNα subtypes, we used the HBV hydrodynamic injection (HI) mouse model. Application of most IFNα subtype proteins inhibited HBV replication in vivo, with IFNα4 and IFNα5 being the most effective subtypes. Decreased viral loads after therapeutic application of IFNα4 and IFNα5 correlated with expanded effector cell populations of NK cells and T cells in both liver and spleen. Hydrodynamic injection of plasmids encoding for the effective IFNα subtypes (pIFNα) was even more potent against HBV than injecting IFNα proteins. The combination of pIFNα4 and pIFNα5 showed a synergistic antiviral effect on HBV replication, with a strong increase in NK cell and T cell activity. The results demonstrate distinct anti-HBV effects of different IFNα subtypes against HBV in the mouse model, which may be relevant for new therapeutic approaches.
format	article
author	Jingjiao Song Sheng Li Yun Zhou Jia Liu Sandra Francois Mengji Lu Dongliang Yang Ulf Dittmer Kathrin Sutter
author_facet	Jingjiao Song Sheng Li Yun Zhou Jia Liu Sandra Francois Mengji Lu Dongliang Yang Ulf Dittmer Kathrin Sutter
author_sort	Jingjiao Song
title	Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
title_short	Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
title_full	Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
title_fullStr	Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
title_full_unstemmed	Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
title_sort	different antiviral effects of ifnα subtypes in a mouse model of hbv infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/23174242175f492487c0baadadc7baf5
work_keys_str_mv	AT jingjiaosong differentantiviraleffectsofifnasubtypesinamousemodelofhbvinfection AT shengli differentantiviraleffectsofifnasubtypesinamousemodelofhbvinfection AT yunzhou differentantiviraleffectsofifnasubtypesinamousemodelofhbvinfection AT jialiu differentantiviraleffectsofifnasubtypesinamousemodelofhbvinfection AT sandrafrancois differentantiviraleffectsofifnasubtypesinamousemodelofhbvinfection AT mengjilu differentantiviraleffectsofifnasubtypesinamousemodelofhbvinfection AT dongliangyang differentantiviraleffectsofifnasubtypesinamousemodelofhbvinfection AT ulfdittmer differentantiviraleffectsofifnasubtypesinamousemodelofhbvinfection AT kathrinsutter differentantiviraleffectsofifnasubtypesinamousemodelofhbvinfection
_version_	1718394385289183232

Different antiviral effects of IFNα subtypes in a mouse model of HBV infection

Ejemplares similares