Effect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial

Abstract Purpose Psychological distresses and pre‐diabetes are among the risk factors of developing type‐II diabetes. The present study was conducted to determine the effectiveness of omega‐3 and vitamin D co‐supplementation on psychological distresses in women of reproductive age with pre‐diabetes...

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Autores principales:	Masoumeh Rajabi‐Naeeni, Mahrokh Dolatian, Mostafa Qorbani, Amir Abbas Vaezi
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	anxiety depression omega‐3 fatty acids prediabetic state vitamin D Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/2317bed4c5e64ccb8db0eef078619303
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spelling	oai:doaj.org-article:2317bed4c5e64ccb8db0eef0786193032021-11-25T06:06:36ZEffect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial2162-327910.1002/brb3.2342https://doaj.org/article/2317bed4c5e64ccb8db0eef0786193032021-11-01T00:00:00Zhttps://doi.org/10.1002/brb3.2342https://doaj.org/toc/2162-3279Abstract Purpose Psychological distresses and pre‐diabetes are among the risk factors of developing type‐II diabetes. The present study was conducted to determine the effectiveness of omega‐3 and vitamin D co‐supplementation on psychological distresses in women of reproductive age with pre‐diabetes and hypovitaminosis D. Methods The present factorial clinical trial was conducted on 168 women of reproductive age with pre‐diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega‐3 group), group 3 (vitamin D group), and group 4 (co‐supplement group). The medication and placebo doses being two 1000‐mg tablets each day for omega‐3 and 50,000‐IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale‐21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention. Results A significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co‐supplementation compared to the other three groups (p < .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (p < .05). Conclusion Vitamin D and omega‐3 co‐supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre‐diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women. Clinical trial registry Iranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.Masoumeh Rajabi‐NaeeniMahrokh DolatianMostafa QorbaniAmir Abbas VaeziWileyarticleanxietydepressionomega‐3 fatty acidsprediabetic statevitamin DNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain and Behavior, Vol 11, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anxiety depression omega‐3 fatty acids prediabetic state vitamin D Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	anxiety depression omega‐3 fatty acids prediabetic state vitamin D Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Masoumeh Rajabi‐Naeeni Mahrokh Dolatian Mostafa Qorbani Amir Abbas Vaezi Effect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial
description	Abstract Purpose Psychological distresses and pre‐diabetes are among the risk factors of developing type‐II diabetes. The present study was conducted to determine the effectiveness of omega‐3 and vitamin D co‐supplementation on psychological distresses in women of reproductive age with pre‐diabetes and hypovitaminosis D. Methods The present factorial clinical trial was conducted on 168 women of reproductive age with pre‐diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega‐3 group), group 3 (vitamin D group), and group 4 (co‐supplement group). The medication and placebo doses being two 1000‐mg tablets each day for omega‐3 and 50,000‐IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale‐21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention. Results A significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co‐supplementation compared to the other three groups (p < .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (p < .05). Conclusion Vitamin D and omega‐3 co‐supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre‐diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women. Clinical trial registry Iranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.
format	article
author	Masoumeh Rajabi‐Naeeni Mahrokh Dolatian Mostafa Qorbani Amir Abbas Vaezi
author_facet	Masoumeh Rajabi‐Naeeni Mahrokh Dolatian Mostafa Qorbani Amir Abbas Vaezi
author_sort	Masoumeh Rajabi‐Naeeni
title	Effect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial
title_short	Effect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial
title_full	Effect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial
title_fullStr	Effect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial
title_full_unstemmed	Effect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial
title_sort	effect of omega‐3 and vitamin d co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis d: a randomized controlled trial
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/2317bed4c5e64ccb8db0eef078619303
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Effect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial

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