Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson's disease.

<h4>Importance</h4>Epidemiologists report a 56% increased risk of veterans with (+) mild traumatic brain injury (mTBI) developing Parkinson's disease (PD) within 12-years post-injury. The most relevant contributors to this high risk of PD in veterans (+) mTBI is unknown. As cognitiv...

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Autores principales:	Vicki A Nejtek, Rachael N James, Michael F Salvatore, Helene M Alphonso, Gary W Boehm
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/231babf1339f4114970e75e107cc46d3
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spelling	oai:doaj.org-article:231babf1339f4114970e75e107cc46d32021-12-02T20:12:56ZPremature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson's disease.1932-620310.1371/journal.pone.0258851https://doaj.org/article/231babf1339f4114970e75e107cc46d32021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258851https://doaj.org/toc/1932-6203<h4>Importance</h4>Epidemiologists report a 56% increased risk of veterans with (+) mild traumatic brain injury (mTBI) developing Parkinson's disease (PD) within 12-years post-injury. The most relevant contributors to this high risk of PD in veterans (+) mTBI is unknown. As cognitive problems often precede PD diagnosis, identifying specific domains most involved with mTBI-related PD onset is critical.<h4>Objectives</h4>To discern which cognitive domains underlie the mTBI-PD risk relationship proposed in epidemiology studies.<h4>Design and setting</h4>This exploratory match-controlled, cross-sectional study was conducted in a medical school laboratory from 2017-2020.<h4>Participants</h4>Age- and IQ-matched veterans with (+) and without mTBI, non-veteran healthy controls, and IQ-matched non-demented early-stage PD were compared. Chronic neurological, unremitted/debilitating diseases, disorders, dementia, and substance use among others were excluded.<h4>Exposure</h4>Veterans were or were not exposed to non-penetrating combat-related mTBI occurring within the past 7-years. No other groups had recent military service or mTBI.<h4>Main outcomes / measures</h4>Cognitive flexibility, attention, memory, visuospatial ability, and verbal fluency were examined with well-known standardized neuropsychological assessments.<h4>Results</h4>Out of 200 volunteers, 114 provided evaluable data. Groups significantly differed on cognitive tests [F (21,299) = 3.09, p<0.0001]. Post hoc tests showed veterans (+) mTBI performed significantly worse than matched-control groups on four out of eight cognitive tests (range: p = .009 to .049), and more often than not performed comparably to early-stage PD (range: p = .749 to .140).<h4>Conclusions and relevance</h4>We found subtle, premature cognitive decline occurring in very specific cognitive domains in veterans (+) mTBI that would typically be overlooked in a clinic setting, This result potentially puts them at-risk for continual cognitive decline that may portend to the eventual onset of PD or some other neurodegenerative disease.Vicki A NejtekRachael N JamesMichael F SalvatoreHelene M AlphonsoGary W BoehmPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0258851 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vicki A Nejtek Rachael N James Michael F Salvatore Helene M Alphonso Gary W Boehm Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson's disease.
description	<h4>Importance</h4>Epidemiologists report a 56% increased risk of veterans with (+) mild traumatic brain injury (mTBI) developing Parkinson's disease (PD) within 12-years post-injury. The most relevant contributors to this high risk of PD in veterans (+) mTBI is unknown. As cognitive problems often precede PD diagnosis, identifying specific domains most involved with mTBI-related PD onset is critical.<h4>Objectives</h4>To discern which cognitive domains underlie the mTBI-PD risk relationship proposed in epidemiology studies.<h4>Design and setting</h4>This exploratory match-controlled, cross-sectional study was conducted in a medical school laboratory from 2017-2020.<h4>Participants</h4>Age- and IQ-matched veterans with (+) and without mTBI, non-veteran healthy controls, and IQ-matched non-demented early-stage PD were compared. Chronic neurological, unremitted/debilitating diseases, disorders, dementia, and substance use among others were excluded.<h4>Exposure</h4>Veterans were or were not exposed to non-penetrating combat-related mTBI occurring within the past 7-years. No other groups had recent military service or mTBI.<h4>Main outcomes / measures</h4>Cognitive flexibility, attention, memory, visuospatial ability, and verbal fluency were examined with well-known standardized neuropsychological assessments.<h4>Results</h4>Out of 200 volunteers, 114 provided evaluable data. Groups significantly differed on cognitive tests [F (21,299) = 3.09, p<0.0001]. Post hoc tests showed veterans (+) mTBI performed significantly worse than matched-control groups on four out of eight cognitive tests (range: p = .009 to .049), and more often than not performed comparably to early-stage PD (range: p = .749 to .140).<h4>Conclusions and relevance</h4>We found subtle, premature cognitive decline occurring in very specific cognitive domains in veterans (+) mTBI that would typically be overlooked in a clinic setting, This result potentially puts them at-risk for continual cognitive decline that may portend to the eventual onset of PD or some other neurodegenerative disease.
format	article
author	Vicki A Nejtek Rachael N James Michael F Salvatore Helene M Alphonso Gary W Boehm
author_facet	Vicki A Nejtek Rachael N James Michael F Salvatore Helene M Alphonso Gary W Boehm
author_sort	Vicki A Nejtek
title	Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson's disease.
title_short	Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson's disease.
title_full	Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson's disease.
title_fullStr	Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson's disease.
title_full_unstemmed	Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson's disease.
title_sort	premature cognitive decline in specific domains found in young veterans with mtbi coincide with elder normative scores and advanced-age subjects with early-stage parkinson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/231babf1339f4114970e75e107cc46d3
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Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson's disease.

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